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Celebration of the ERC Funding in Life Sciences

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INEM is proud to announce The Celebration of the European Research Council Funding in Life Sciences: From Fundamental Discoveries to Innovative Life-Saving Therapies Symposium, an event co-organised with Association of ERC Grantees, Académine Nationale de Médecine de France and the Ministry of Higher Education and Research, set to showcase the pivotal role of European Research Council (ERC) funding in advancing life sciences research and innovation.

 

 

 

Highlights of the symposium

Matthieu Mahévas - Chaires d’excellence en Biologie Santé - France 2030

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INEM proudly announces Matthieu Mahévas as one of the esteemed awardees of the "Chaires d’Excellence en Biologie-Santé" under the France 2030 Initiative.

The Chairs of Excellence in Biology-Health program, overseen by the French National Research Agency, provides top researchers from diverse backgrounds with significant funding to launch major new projects in France for five years.

Visit of The French-Chinese Committee for Science & Technology

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For the 15th edition of the Franco-Chinese Joint Committee for Science and Technology, Institut Necker Enfants Malades welcomed the Minister of Higher Education and Research, Sylvie Retailleau, as well as the Minister of Science and Technology of the People's Republic of China, Mr. Yin Hejun.

This visit provided an opportunity to highlight the excellence of research conducted in France, particularly within our Institute, and to discuss crucial topics such as healthy aging of the population, a research theme explored by two teams within the Institute.

Celebrating Women in Science

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At INEM, we take immense pride in our commitment to advancing science through diversity and inclusion. Today, we celebrate three remarkable women from our institute who have not only excelled in their scientific endeavors but have also served as inspiring role models for aspiring scientists worldwide.

Immunoregulatory potential of antimicrobial peptides and gut microbiota in type 1 diabetes

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Type 1 Diabetes (T1D) results from immune attacks on pancreatic beta cells by T lymphocytes. Our research focuses on the gut microbiota's role in preventing this autoimmunity. We've explored cathelicidin's involvement in T1D and extended our investigation to other antimicrobial peptides (AMPs), specifically mBD14. Our findings show mBD14's expression in pancreatic cells is crucial for preventing T1D in NOD mice, as it stimulates regulatory B cells via TLR2, leading to protective immune responses. Further, mBD14's expression is influenced by gut microbiota metabolites and genetic factors.

Resonsable axe
DIANA

Primary cilia function in kidney mechano-surveillance and inflammation

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The kidney removes waste, water and solute from the body to maintain a constant composition of the fluid that bathes our cells (i.e., homeostasis). To do so, the kidney filters around 180 litres of plasma each day through the glomeruli. This filtrate then enters kidney tubules, which reabsorbed molecules that need to be retained to achieve homeostasis, thereby concentrating unwanted wastes in the final urine.

Resonsable axe
BIENAIME

Guillaume Canaud: hope for CLOVES

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Marine Lamoureux from La Croix L'hebdo followed Pr Guillaume Canaud and his teams at Hôpital Necker Enfants Malades for an incredible six-month journey - the treatment of children with CLOVES Syndrome.

CLOVES Syndrome is a very rare congenital disorder characterized by a combination of vascular, skin, spinal, and bone or joint abnormalities. Pr Canaud discovered a treatment, thus a turning point in the lives of these patients and their families.

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