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David Sabatini

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David M. Sabatini studies nutrient sensing and growth control, particularly by the mechanistic Target of Rapamycin (mTOR) pathway. This pathway is the major nutrient-sensitive growth regulator in animals and plays a central role in physiology, metabolism, aging, and cancer. Sabatini discovered the mTOR protein kinase, and most other components of the pathway, including the mTOR-containing complexes mTORC1 and mTORC2, and established them as growth regulators in cells and in vivo.

Metabolism

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Research in this area explores how metabolic cues regulate immune responses, cellular growth, and tissue function, with particular attention to nutrient sensing, hormonal signaling, and metabolic disorders.

Cell Plasticity & Regeneration

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This area explores how cells and tissues adapt, remodel, and repair in response to stress, damage, or disease. Research covers stem cell dynamics, immune and hormonal plasticity, and the molecular pathways driving regeneration, with implications for cancer, chronic inflammation, and regenerative medicine.

Cross Cutting Edges funding awarded to Nicolas Dupont for the PolluRein project

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Nicolas Dupont has been awarded funding from Université Paris Cité as part of the Crossing Cutting Edges call for proposals, for the project PolluRein (The role of atmospheric particulate matter in chronic kidney disease progression), in collaboration with Prof. Patrice Coll’s laboratory (Laboratoire Interuniversitaire des Systèmes Atmosphériques LISA – UMR 7583).

INEM Scientific Photo Contest – 2025 Edition

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We are thrilled to announce the winners of the 2nd INEM Scientific Photo Contest, which once again highlighted the creativity and scientific diversity of our institute. From cellular landscapes to experimental snapshots, this year’s submissions showcased the fascinating beauty of science.

Jury’s Choice Awards

1st Prize – Mathieu Deygas — Neutro In Vitraux
2nd Prize – Tahina Randresy — First-ever Stem Cells Capable of Growing Forests
3rd Prize – Ana Raquel Cruz — Brief Encounters

Public Vote Winners