Welcome on the Necker-Enfants Malades Institute website
  • Autophagie et cil primaire dans la traduction de forces physiques en réponse biologique dans le rein

    Une étude dirigée par Patrice Codogno et Nicolas Dupont (Equipe Etienne Morel), publiée récemment dans Nature Cell Biology a montré le rôle des forces de cisaillement, [...]

  • Autophagy and primary cilium in the translation of physical forces to biological responses in kidney.

    A work headed by Patrice Codogno and Nicolas Dupont (Team Etienne Morel), recently published in Nature Cell Biology showed the role of shear stress generated by urinary fluid flow on the regulation of the metabolism of epithelial cells from the renal proximal tubular [...]

  • A collaboration between the Pende, Terzi and Pontoglio groups reveals pathological mechanisms in polycystic kidneys.

    Polycystic kidney is a debilitating condition observed in several genetic diseases, including Ciliopathies, Autosomal Dominant Polycystic Kidney Disease (ADPKD) and Tuberous Sclerosis Complex. This disorder is accompanied by the activation [...]

  • Group leader position available at Institut Necker Enfants Malades, Necker Campus, Paris
    INEM is now seeking to complement its scientific teams by recruiting a new junior or established group leader in areas relevant to its mission, who combines scientific excellence in fundamental research approaches with a strong interest in disease-relevant investigation.
    Applications should be submitted by August 31, [...]
  • Simon Fillatreau, Matthieu Mahévas, Claude-Agnès Reynaud and Jean-Claude Weill have received funding from the French National Research Agency (ANR)

    Do patients who recovered from COVID-19 possess an immunological memory protecting them against reinfection? If so for how long? Will it vary depending on the [...]

  • L’équipe Morel fait sortir la PI3KC2α de l’ombre lors de la réponse autophagique au stress mécanique
    Le processus de dégradation cellulaire appelé autophagie peut être induit par l’absence de nutriments, mais également par le stress mécanique, comme celui provoqué par les forces de cisaillements à la surface des cellules polarisées. Cette [...]
The Institute
The Institut Necker-Enfants Malades (INEM), created in January 2014, is an international biomedical research center located on the Necker Hospital campus, and supported by the French National Institute of Health and Medical Research (INSERM), the French National Center for Scientific Research (CNRS) and the University Paris Descartes.

Research at INEM is focusing on common diseases caused by the interplay of polygenic inheritance and environmental factors. These diseases primarily affect children and the young, and encompass (auto)immune disorders, haematological diseases, infectious diseases, kidney diseases, cystic fibrosis, endocrinological disorders and metabolic diseases. The INEM teams apply insights obtained through basic and clinical research to develop innovative diagnostic and therapeutic strategies.

For over 40 years, the development of renal transplants and bone marrow transplants, the phenotyping of autoimmune diseases and genetic diseases, allowed most of the major medical advances of today. The major asset of the Institute Necker-Enfants Malades comes from the plurality of skills, the freedom and creativity of its researchers, their desire to diversify their research topics.

Translational activities will be pursued and promoted as much as possible. Indeed, this group of PIs has filed 24 patents, 4 of which are licenced to pharmaceutical companies. 13 R&D contracts have been signed with industry and 3 start-up companies incorporated with one of the above PIs as founder. To further strengthen the link with the socio-economic world, we intend to devote one floor of our research building to hosting private entities, either small companies or teams from bigger pharmaceutical industries wishing to collaborate with groups of the Necker-Enfants Malades Institute.

Our mission

The close interaction between the research labs and the clinical departments is one of our major strengths creating a highly dynamic environment and promoting translational and “bench to bedside” activities. Our research programs are consistent with this mission and most groups have very tight connections with the clinics, mostly through clinicians with joint appointments in research labs and clinical departments.

Our research in the coming years will focus on:
  • Understanding the molecular mechanisms of leukemia is to use targeted therapies and avoid chemotherapy whose collateral damage is known
  • Defeating diabetes, especially the type 1 in children (440,000 in the world), is to address the treatment of autoimmune diseases, more and more frequent in developed countries, as the case for multiple sclerosis or lupus.
  • Succeed one day to control the immune system, thanks to the long experience and considerable clinical material at the Necker hospital on kidney and bone marrow transplantations, is a priority
  • Seek to determine the mechanisms responsible for bacterial meningitis, debilitating in a few hours a perfectly healthy child or subject, is essential to develop effective and safe vaccines.
  • Apply our knowledge of metabolism and growth to promote innovative and personalized therapies in the field of kidney disease, diabetes, cystic fibrosis, muscular dystrophy and various solid tumors.
The Necker-Enfants Malades Institute is administered by one Director assisted by the two department Heads and one General secretary in charge the administration. Each PI or CoPI is responsible for his (her) scientific project and for the use of his (her) allocated space
Fabiola Terzi
INEM Director
Mario Pende
Marco Pontoglio
Director of "Growth and Signalling" Dept
Peter Van Endert
Simon Fillatreau
Director of "Immunology, Infectiology and Haematology" (I2H) Dept
Sophie Koutouzov
General Secretary
The scientific teams
The people of INEM

Thirteen research teams are founding members of the Necker-Enfants Malades Institute, which comprises today 19 research teams. The teams are grouped in two departments: a department of cell biology (Growth and Signalling) and a department of, Immunology, Infectiology and Haematology (I2H).

The Necker-Enfants Malades Institute currently comprises 103 senior scientists, one third of whom are medical doctors, 60 technicians and engineers, 35 postdoctoral fellows and 37 PhD students. Among the 19 teams, 7 have already obtained an award from the European Research Council.

Contact us
+33 (0)1 40 61 53 00
Institut Necker Enfants Malades

Faculté de Médecine Necker
160, rue de Vaugirard
75015 Paris Cedex
HRH Princess Caroline of Hanover, who through the Princess Grace Foundation, already supports medical research and anything that helps to relieve the sick children in France and around the world, has agreed to commit to our side so that our Center of Molecular medicine continues to meet the current challenges and fight diseases, and in particular the ones affecting children.

INEM - Organigramme