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Université Paris Cité
ED 562 - Biologie Sorbonne Paris Cité (BioSPC)
Sujet de thèse :S6 kinases as therapeutic targets against the Tuberous Sclerosis mTORopathy and related neural alteration
Directeur.trice de thèse : Mario Pende


I obtained my Master Degree of Gene, Cell Development at the Versailles-Saint-Quentin-en-Yvelines University. I joined Mario Pende’s team for my undergraduate project and started to study the underlying mechanisms of mTOR pathway controlling the neuroplasticity. I worked on neural progenitor cells to identify new mTOR substrates involved in brain function. In 2020, I was able to obtain an FRM fellowship and start my PhD project on rare diseases. I aim to decipher the molecular mechanisms of ependymal cell development by the mTOR Pathway. In my project I showed that a rapamycin sensitive mTOR pathway is required for cell growth, centriole amplification and formation of multi-ciliated cells.