Welcome on the Necker-Enfants Malades Institute website
  • Target of Rapamycin science club in France

    22-23 May 2018

    Target Of Rapamycin (TOR) signal transduction has an evolutionary conserved role in the control of growth, metabolism and ageing depending on nutrient availability. We aim at promoting a Science Club on TOR signal transduction in France, "le TOR de France". The goal is to gather students, postdocs, group leaders working in the field of TOR, nutrition, growth, development [...]
  • Cours pour les étudiants en Ecole Doctorale - Graduate lecture series: The basis of tissue growth

    March 12-15, 2018

    In collaboration with Inserm and Université Paris-Descartes
  • Claude-Agnès Reynaud et Jean-Claude Weill, Prix d’Honneur INSERM 2017
    Claude-Agnès Reynaud, directrice de recherche CNRS, et Jean-Claude Weill, professeur émérite d’immunologie à la faculté de médecine de Paris Descartes, travaillent côte à côte depuis 1981, dans le domaine de l’immunologie adaptative, et co-dirigent l’équipe « Développement du Système Immunitaire »  à l’INEM depuis 2014. Claude-Agnès Reynaud et Jean-Claude Weill [...]
  • Call 2017 for INEM New Teams
    The Institut Necker Enfants Malades (INEM), located in the heart of Paris, is a research centre that develops approaches of molecular medicine based on frontline fundamental research. INEM works in close interaction with the Necker Hospital that provides care for pediatric and adult pathologies in a medical tradition of excellence. This environment fosters interdisciplinary research, both fundamental and translational.INEM wishes to recruit one or several team heads to join its department of immunology, microbiology and hematology. Candidates are expected to be dynamic, [...]
  • Hommage à Yves de Keyzer
    C’est avec une grande tristesse que nous apprenons le décès aujourd’hui de Yves de Keyzer, Directeur de Recherche à l’Inserm. Depuis les années ’80 jusqu’à présent, Yves a marqué par sa curiosité et affabilité plusieurs laboratoires des sites Cochin et Necker à l’Université Paris Descartes. Pendant sa formation doctorale et post-doctorale, Yves a travaillé avec les Prof. [...]
  • L’homéostasie du fer : un nouveau talon d’Achille des cellules souches cancéreuses.
    Salinomycin kills cancer stem cells by sequestering iron in lysosomes Trang Thi Mai, Ahmed Hamaï, Antje Hienzsch, Tatiana Cañeque, Sebastian Müller, Julien Wicinski, Olivier Cabaud, Christine Leroy, Amandine David, Verónica Acevedo, Akihide Ryo, Christophe Ginestier, Daniel Birnbaum, Emmanuelle Charafe-Jauffret, Patrice Codogno, Maryam Mehrpour & Raphaël Rodriguez. Nature Chemistry (2017) [...]
The Institute
The Institut Necker-Enfants Malades (INEM), created in January 2014, is an international biomedical research center located on the Necker Hospital campus, and supported by the French National Institute of Health and Medical Research (INSERM), the French National Center for Scientific Research (CNRS) and the University Paris Descartes.

Research at INEM is focusing on common diseases caused by the interplay of polygenic inheritance and environmental factors. These diseases primarily affect children and the young, and encompass (auto)immune disorders, haematological diseases, infectious diseases, kidney diseases, cystic fibrosis, endocrinological disorders and metabolic diseases. The INEM teams apply insights obtained through basic and clinical research to develop innovative diagnostic and therapeutic strategies.

For over 40 years, the development of renal transplants and bone marrow transplants, the phenotyping of autoimmune diseases and genetic diseases, allowed most of the major medical advances of today. The major asset of the Institute Necker-Enfants Malades comes from the plurality of skills, the freedom and creativity of its researchers, their desire to diversify their research topics.

Translational activities will be pursued and promoted as much as possible. Indeed, this group of PIs has filed 24 patents, 4 of which are licenced to pharmaceutical companies. 13 R&D contracts have been signed with industry and 3 start-up companies incorporated with one of the above PIs as founder. To further strengthen the link with the socio-economic world, we intend to devote one floor of our research building to hosting private entities, either small companies or teams from bigger pharmaceutical industries wishing to collaborate with groups of the Necker-Enfants Malades Institute.

Our mission

The close interaction between the research labs and the clinical departments is one of our major strengths creating a highly dynamic environment and promoting translational and “bench to bedside” activities. Our research programs are consistent with this mission and most groups have very tight connections with the clinics, mostly through clinicians with joint appointments in research labs and clinical departments.

Our research in the coming years will focus on:
  • Understanding the molecular mechanisms of leukemia is to use targeted therapies and avoid chemotherapy whose collateral damage is known
  • Defeating diabetes, especially the type 1 in children (440,000 in the world), is to address the treatment of autoimmune diseases, more and more frequent in developed countries, as the case for multiple sclerosis or lupus.
  • Succeed one day to control the immune system, thanks to the long experience and considerable clinical material at the Necker hospital on kidney and bone marrow transplantations, is a priority
  • Seek to determine the mechanisms responsible for bacterial meningitis, debilitating in a few hours a perfectly healthy child or subject, is essential to develop effective and safe vaccines.
  • Apply our knowledge of metabolism and growth to promote innovative and personalized therapies in the field of kidney disease, diabetes, cystic fibrosis, muscular dystrophy and various solid tumors.
The Necker-Enfants Malades Institute is administered by one Director assisted by the two department Heads and one General secretary in charge the administration. Each PI or CoPI is responsible for his (her) scientific project and for the use of his (her) allocated space
Xavier Nassif
INEM Director
Fabiola Terzi
Director of "Growth and Signalling" Dept
Peter Van Endert
Director of "Immunology, Infectiology and Haematology" (I2H) Dept
Sophie Koutouzov
General Secretary
The people of INEM

Thirteen research teams are founding members of the Necker-Enfants Malades Institute, which comprises today 17 research teams. The teams are grouped in two departments: a department of cell biology (Growth and Signalling) and a department of, Immunology, Infectiology and Haematology (I2H).

The Necker-Enfants Malades Institute currently comprises 103 senior scientists, one third of whom are medical doctors, 60 technicians and engineers, 35 postdoctoral fellows and 37 PhD students. Among the 17 teams, 4 have already obtained an award from the European Research Council.

Contact us
+33 (0)1 72 60 63 90
+33 (0)1 72 60 64 05
Institut Necker Enfants Malades

Faculté de Médecine Paris Descartes
Bâtiment Leriche - Etage 4
14 Rue Maria Helena Vieira da Silva

75993 Paris Cedex 14
HRH Princess Caroline of Hanover, who through the Princess Grace Foundation, already supports medical research and anything that helps to relieve the sick children in France and around the world, has agreed to commit to our side so that our Center of Molecular medicine continues to meet the current challenges and fight diseases, and in particular the ones affecting children.

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