Seminar topic: The inactive X chromosome: a genetic driver of sex differences in nucleic acid immunity

Jean-Charles Guéry currently holds a position of Research Director at the French Institute of Health and Medical Research (INSERM) at the Toulouse Institute for Infectious and Inflammatory Diseases (INFINITY). He is the Principal Investigator of the Team “Sex differences in immunity: mechanisms and pathophysiology". He received his PhD in Immunology in 1990 at Diderot University in Paris. During his post-doctoral research experience in Sandoz (Basle, Switzerland) and then Hoffman-La Roche (Milano, Italy) he studied several aspects of self and non-self antigen presentation by dendritic cells in vivo and their impact on tolerance induction and adaptive T cell immunity. He established his own group at INSERM, University of Toulouse in 1995. Over the past 20 years, he focused his research interest in the understanding of the mechanisms responsible for sex-related differences in immunity. Recent works in his lab sustain the hypothesis that sex hormones and sex-chromosome loci, may act in a cell-intrinsic manner to regulate the development, maintenance or functional responses of specific cellular subsets of the innate and adaptive immune system, thereby controlling the sex differences in immune related disorders (allergy, autoimmunity, susceptibility to infections). 


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