Biosketch

Guillaume Darrasse-Jèze is a Principal Investigator at INEM and an Associate Professor of Immunology at the Faculty of Medicine of Paris City University, where he holds the Inserm Chair of Biotherapy. He completed his PhD on regulatory T cell (Treg) homeostasis under the supervision of Prof. David Klatzmann at Pierre and Marie Curie (Sorbonne) University and his postdoctoral training on the biology of dendritic cells and their role in immune tolerance under the guidance of Prof. Michel Nussenzweig at Rockefeller University (New York, USA). 

He and his team seek to understand how the immune system decides between maintaining tolerance and initiating immune responses. To address this question, they study interactions between dendritic cells, Tregs, and natural killer (NK) cells at the genetic, molecular, and cellular levels. This cellular network maintains immune homeostasis in physiological contexts such as pregnancy but can also restrain anti-tumor immunity. Its dysregulation contributes to autoimmune diseases, recurrent miscarriage, and pregnancy complications, notably intrauterine growth restriction and preeclampsia. 

By deciphering these interactions, his group aims to uncover fundamental principles of immune regulation and identify new strategies to therapeutically modulate immune responses.