Dr. Oury graduated in neurobiology (2007) at the Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC, Strasbourg, France) in the laboratory of Dr. Filippo Rijli. He then moved to Columbia University (New York, USA), in the laboratory of Dr. Gérard Karsenty (2006-2014), where he gained expertise in neuro- and integrative physiology, identifying novel endocrine functions of the skeleton for the regulation of gonadal, pancreatic and brain functions. Since 2014, he is heading a research team at the Institut Necker Enfants-Malades (INEM) in Paris, supported by the ATIP-Avenir, HFSP, FRM, ANR, Emergence de la ville de Paris, AGEMED et FSER program. He has obtained a permanent INSERM position as CR1 in 2014 and as DR2 in 2019. His group has been recently labeled FRM team (2019) and he is a core member of the Aging INSERM national program.
His team is currently using an interdisciplinary approach to understand how brain functions are modulated by hormonal factors. Most recent work led him to investigate the role of neuronal autophagy has an essential mediator of the hormonal regulation of brain cognitive fitness, plasticity and aging. In addition, His laboratory has a particular interest in developing novel therapies to treat age-related cognitive disorders and associated diseases.
The main focus of my laboratory is to investigate the roles played by hormonal factors on the regulation of brain cognitive functions in normal, pathological and aging conditions.
Hormones are essential factors ensuring proper regulation of our physiological functions by mediating dialogue between organs. Their broad spectrum of actions is not limited to the peripheral organs. Some hormonal factors, such as leptin, insulin, thyroid hormones, steroid hormones reach the central nervous system (CNS) where they modulate the central regulation of whole-body metabolism.
Recently, it has been shown that they can also influence more intrinsic functions of the CNS, such as brain development, adult neurogenesis and cognitive functions. Importantly, increasing evidence suggests that changes in their circulating levels may contribute to age-related cognitive decline, as well as to the development of neurodegenerative diseases. While the functional importance of hormonal factors on brain activities is undeniable, their cellular and molecular mechanisms of action are unclear. Moreover, although the brain expresses receptors for most, if not all, hormonal factors, the role(s) of many hormones in the CNS remain unexplored. Characterizing the influence of hormonal homeostasis during aging may open up new roads for therapeutic intervention to ameliorate age- and disease-related cognitive impairments, and reverse/prevents age-related memory decline.
While it is evident that hormonal factors are essential to mediate communication between our peripheral organs and the central nervous system, we have an imcomplete understanding of the roles played by hormonal factors in controling brain metabolic and cognitive functions (in healthy and aging population).
The overall research goals of my laboratory are:
We are currently using an interdisciplinary approach that combines mouse genetics, cellular and molecular methodologies, local brain stereotactic injections, lentiviral-based gene downregulation, primary neuronal cells-based assays, and behavioral/metabolic analyses, to answer these questions. For the translational aspects of my projects, we have multiple collaborations with clinicians at Paris Descartes-Sorbone Cité campus.