The main focus of our research team is to understand how mammalian cells mobilize organelles, endomembrane-based signaling platforms and autophagic machinery to adapt to stress situations and external stimuli.
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Mammalian intracellular compartments are highly regulated and renewed to ensure the maintaining of proper cell physiology. In this dynamic context, the intracellular degradative autophagy pathway probably takes advantages of – and initiates dialogs with - pre-existing signaling platforms, organelles and endomembranes. Although there is low-level basal activity, autophagy is mostly associated with stress responses and is considered as an acute protective system that ensures cell homeostasis and contributes directly to cell metabolism and energy regulation. Accordingly, autophagy participates in development, immunity and protects against cell modifications related to ageing. Autophagy involves the formation, and subsequent trafficking, of autophagosomes, which arise from the closure of transient cup-shaped double-membrane structure termed phagophore that capture cytoplasmic cargos for a final delivery to lysosomes. Studying the crosstalk of autophagic machinery with other cellular organelles and structures, such as mitochondria, endosomes and primary cilia, will shed light on the importance of endomembranes and signaling platforms cooperation in stress sensing and homeostasis regulation in a wide variety of mammalian cells.
Our project aims at investigating the cellular and molecular mechanisms that regulate autophagic pathway during stress response in cooperation with other endomembranes, in physiological and pathophysiological situations.
3 interconnected axes are currently investigated in my laboratory:
Keywords: autophagic membranes and machinery, chemical, nutritional, infectious and mechanical stresses, primary cilium, endosomes, mitochondria, metabolism, membrane dynamics and contact-sites.
My main interest in biology concerns intracellular compartments membrane dynamics, trafficking and interconnections. I obtained my PhD in Physiology and Cell Biology at Pierre et Marie Curie Paris 6 University (2003) and then specialized myself on endosomal membrane dynamics (Postdoc #1 (2004-2009), University of Geneva, Dept of Biochemistry, Geneva, CH) and on biology of phosphoinositides on endosomal features of Alzheimer’s disease (Postdoc #2 (2009-2010), Columbia University, Cell Biology and Pathology Dept, NYC, USA). After having a permanent position at Inserm, I studied the role of autophagy in alimentary lipids behavior in human enterocytes (Centre de Recherches des Cordeliers (2010-2013), Paris) and I then joined the Cell Biology department of Institut Necker Enfants Malades in 2014 to develop projects on basic autophagy in the context of stress sensing. The research goal of my team is to understand how mammalian cells organelles cooperate with autophagic machinery to respond to stress stimuli.