Five major original publications
Boukhalfa A., Roccio F., Dupont N., Codogno P., Morel E. (2021). The autophagy protein ATG16L1 cooperates with IFT20 and INPP5E to regulate the turnover of phosphoinositides at the primary cilium. Cell Reports. Apr 27;35(4):109045. doi: 10.1016/j.celrep.2021.109045
Molino D., Pila-Castellanos I., Marjault H.B., Amoedo N.D., Kopp K., Rochin L., Karmi O., Sohn Y.S., Lines L., Hamaï A., Joly S., Radreau P., Vonderscher J., Codogno P., Giordano F., Machin P., Rossignol R., Meldrum E., Arnoult D., Ruggieri A., Nechushtai R., De Chassey B., Morel E. (2020). Chemical targeting of NEET proteins reveals their function in mitochondrial morphodynamics. EMBO Reports. Dec 3;21(12):e49019. doi: 10.15252/embr.201949019
Miceli C., Roccio F., Penalva-Mousset L., Burtin M., Leroy C., Nemazanyy I., Friedlander G., Morel E., Terzi F., Codogno P., Dupont N. (2020). The primary cilium and lipophagy translate mechanical forces to direct metabolic adaptation of kidney epithelial cells. Nature Cell Biology. Sep;22(9):1091-1102. doi: 10.1038/s41556-020-0566-0
Boukhalfa A., Nascimbeni A.C., Ramel D., Dupont N., Hirsch E., Gayral S., Laffargue M., Codogno P., Morel E. (2020). PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress. Nature Communications. Jan 15;11(1):294. doi: 10.1038/s41467-019-14086-1
Nascimbeni A.C., Giordano F., Dupont N., Grasso D., Vaccaro M.I., Codogno P., Morel E. (2017). ER-plasma membrane contact sites contribute to autophagosome biogenesis by regulation of local PI3P synthesis. EMBO Journal. Jul 14;36(14):2018-2033. doi: 10.15252/embj.201797006
List of publications
2022
Membrane protective role of autophagic machinery during infection of epithelial cells by Candida albicans
Lapaquette P, Ducreux A, Basmaciyan L, Paradis T, Bon F, Bataille A, Winckler P, Hube B, d'Enfert C, Esclatine A, Dubus E, Bringer MA, Morel E and Dalle F
Gut Microbes 2022 Jan
2021
Role of mitochondrial morphodynamics and contact sites in the antiviral response
De Chassey B and Morel E
Médecine/Sciences 2021 Dec
Primary cilium-dependent autophagy in the response to shear stress
Morel E, Dupont N and Codogno P
Biochemistry Society Transactions 2021 Dec
ATG9A protects plasma membrane from programmed and incidental permeabilization
Claude-Taupin A, Jia J, Bhujabal Z, Garfa-Traoré M, Kumar S, Peixoto Duarte da Silva G, Javed R, Gu Y, Allers L, Peters R, Wang F, Jesus da Costa L, Pallikkuth S, Lidke KQ, Mauthe M, Verlhac P, Uchiyama Y, Salemi M, Phinney B, Tooze S.A, Mari M.C, Johansen T, Reggiori F, and Deretic V
Nature Cell Biology 2021 June
When the autophagy protein ATG16L1 met the ciliary protein IFT20
Boukhalfa A, Roccio F, Dupont N, Codogno P and Morel E
Autophagy 2021 May
The autophagy protein ATG16L1 cooperates with IFT20 and INPP5E to regulate the turnover of phosphoinositides at the primary cilium
Boukhalfa A, Roccio F, Dupont N, Codogno P# and Morel E#
Cell Reports 2021 Apr
ATG4D is the main ATG8 delipidating enzyme in mammalian cells and protects against cerebellar neurodegeneration
Tamargo-Gómez I, Martínez-García G, Suárez M, Rey V, Fueyo A, Codina-Martínez H, Tomás-Zapico C, Bretones G, M. Caravia X, Morel E, Dupont N, Cabo R, Souquere S, Pierron G, Codogno P, López-Otín C, Fernández A, and Mariño G
Cell Death & Differentiation 2021 Apr
The ménage à trois of autophagy, lipid droplets and liver disease
Filali-Mouncef Y, Hunter C, Roccio F, Zagkou S, Dupont N, Primard C, Proikas-Cezanne T, Reggiori F
Autophagy 2021 Apr
Monitoring lipophagy in kidney epithelial cells in response to shear stress
Roccio F, Claude-Taupin A, Botti J, Morel E, Codogno P and Dupont N
Methods in Cell Biology 2021 March
Mitochondrial morphodynamics alteration induced by influenza virus infection as a new antiviral strategy
Pila-Castellanos I*, Molino D*, McKellar J, Lines L, Da Graca J, Tauziet M, Chanteloup L, IMikaelian, Meyniel-Schicklin L, Codogno P, Vonderscher J, Delevoye C, Moncorgé O, Meldrum E, Goujon C, Morel E# and De Chassey B#
PLoS Pathogens 2021 Feb
Phosphoinositides: functions in autophagy-related stress responses
Claude-Taupin A and Morel E
BBA Molecular and Cellular Biology of Lipids 2021 Feb
The lipid kinase hidden behind the PI3P: a specific dialog between the primary cilium and autophagic machinery
Codogno P, Dupont N and Morel E
Medecine/Sciences 2021 Jan
2020
Fluid flow-induced shear stress controls the metabolism of proximal tubule kidney epithelial cells through primary cilium dependent lipophagy and mitochondrial biogenesis
Miceli C*, Roccio F*, Penalva-Mousset L*, Morel E, Codogno P# and Dupont N#
Autophagy 2020 Dec
Chemical targeting of NEET proteins reveals their function in mitochondrial morphodynamics
Molino D*, Pila-Castellanos I*, Marjault HB, Amoedo ND, Kopp K, Rochin L, Karmi O, Sohn YS, Lines L, Hamaï A, Joly S, Radreau P, Vonderscher J, Codogno P, Giordano F, Machin P, Rossignol R, Meldrum E, Arnoult D, Ruggieri A, Nechushtai R, De Chassey B# and Morel E#
EMBO Reports 2020 Nov
The primary cilium and lipophagy translate mechanical forces to direct metabolic adaptation ; of kidney epithelial cells
Miceli C*, Penalva-Mousset L*, Roccio F*, Burtin M, Leroy C, Nemazanyy I, Friedlander G, Morel E, Terzi F, Codogno P# and Dupont N#
Nature Cell Biology 2020 Aug
Ultrastructural and dynamic studies of the endosomal compartment in Down syndrome
Botté A, Lainé J, Xicota L, Heiligenstein X, Fontaine G, Kasri A, Rivals I, Goh, P, Faklaris O, Cossec JC, Morel E, Rebillat AS, Nizetic D, Raposo G and Potier MC
Acta Neuropathologica Communications 2020 July
Primary cilium-dependent autophagy drafts PIK3C2A to generate PI3P in response to shear stress
Boukhalfa A*, Nascimbeni AC*, Dupont N, Codogno P and Morel E
Autophagy 2020 June
ER membrane and contact sites dynamics in autophagy regulation and stress response
Morel E
Frontiers in Cell and Developmental Biology 2020 May
PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress
Boukhalfa A*, Nascimbeni AC*, Ramel D, Dupont N, Hirsch E, Gayral S, Laffargue M, Codogno P# and Morel E#
Nature Communications 2020 Jan
2019
Interplay between primary cilia, ubiquitin-proteasome system and autophagy
Boukhalfa A*, Miceli C*, Ávalos Y, Morel E and Dupont N
Biochimie 2019 July
The primary cilium protein folliculin is part of the autophagy signalling pathway to regulate epithelial cell size in response to fluid flow
Zemirli N*, Boukhalfa A*, Dupont N, Botti J, Codogno P and Morel E
Cell Stress 2019 Feb
Monitoring of Autophagy and Cell Volume Regulation in Kidney Epithelial Cells in Response to Fluid Shear Stress
Lazari MM, Orhon I, Codogno P, Dupont N.
Methods Mol Biol. 2019
Autophagy is required for memory formation and reverses age-related memory decline
Glatigny M*, Moriceau S*, Ramos-Brossier M*, Nascimbeni AC, Shanley MR, Rivagorda M, Boudarene N, Rousseaud A, Settembre C, Kuperwasser N, Friedlander G, Friedman AK, Morel E, Codogno P and Oury F.
Current Biology 2019 Jan
2018
A novel regulator of autophagosome biogenesis and lipid droplet dynamics
Morel E and Codogno P.
EMBO Reports 2018 Sept
FOXO3a provides a quickstep from autophagy inhibition to apoptosis in cancer therapy
Codogno P and Morel E.
Developmental Cell 2018 Mar
Mitochondrial dynamics in basal and stressful conditions
Zemirli N, Morel E and Molino D.
International Journal of Molecular Science 2018 Feb
Cholesterol trafficking and raft-like membrane domain composition mediate scavenger receptor class B type 1-dependent lipid sensing in intestinal epithelial cells
Morel E, Ghezzal S, Lucchi G, Truntzer C, Pais de Barros JP, Simon-Plas F, Demignot S, Mineo C, Shaul PW, Leturque A, Rousset M and Carriere V.
BBA Molecular And Cellular Biology of Lipids 2018 Feb
2017
ER-driven membrane contact sites: evolutionary conserved machineries for stress response and autophagy regulation?
Molino D, Nascimbeni AC, Giordano F, Codogno P and Morel E.
Communicative & Integrative Biology 2017 Dec
To be or not be cell-autonomous? Autophagy says both
Fenouille N, Nascimbeni AC, Botti-Millet J, Dupont N, Morel E and Codogno P
Essays in Biochemistry 2017 Dec
Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow.
Vion AC, Kheloufi M, Hammoutene A, Poisson J, Lasselin J, Devue C, Pic I, Dupont N, Busse J, Stark K, Lafaurie-Janvore J, Barakat AI, Loyer X, Souyri M, Viollet B, Julia P, Tedgui A, Codogno P, Boulanger CM, Rautou PE.
Proc Natl Acad Sci U S A. 2017 Oct
Local detection of PI3P at autophagosome biogenesis membrane platforms
Nascimbeni AC, Codogno P and Morel E.
Autophagy 2017 Sept
Autophagosomal membranes assemble at ER-plasma membrane contact sites
Nascimbeni AC, Codogno P and Morel E.
Molecular and Cellular Oncology 2017 July
Cellular and molecular mechanism for secretory autophagy.
Kimura T, Jia J, Claude-Taupin A, Kumar S, Choi SW, Gu Y, Mudd M, Dupont N, Jiang S, Peters R, Farzam F, Jain A, Lidke KA, Adams CM, Johansen T, Deretic V.
Autophagy. 2017 Jun
ER-plasma membrane contact sites contribute to autophagosome biogenesis ; by regulation of local PI3P synthesis
Nascimbeni AC, Giordano F, Dupont N, Grasso D, Vaccaro MI, Codogno P and Morel E.
EMBO Journal 2017 May
PI3P in the regulation of autophagy membrane dynamics
Nascimbeni AC, Codogno P and Morel E.
FEBS Journal 2017 May
The biogenesis of autophagosome: a new challenge for the cell biologist
Morel E.
Médecine/Sciences 2017 Mar
The journey of the autophagosome through mammalian cell organelles and membranes
Molino D, Zemirli N, Codogno P and Morel E.
Journal of Molecular Biology 2017 Feb
Autophagy: a Druggable Process
Morel E, Mehrpour M, Botti J, Dupont N, Hamaï A, Nascimbeni AC and Codogno P.
Annual Reviews in Pharmacology and Toxicology 2017 Jan