Bienvenu(e) sur le site de l'Institut Necker Enfants Malades

Comprendre les mécanismes controllant la chronicité et la sévérité des pathologies autoimmunes et infectieuses

de la science fondamentale :
  • immunité innée et adaptative
  • régulation des réponses immunitaires
à la recherche translationnelle :
  • maladies infectieuses
  • maladies autoimmunes
Simon Fillatreau
Immunité normale et pathologique
S. Fillatreau studied biology at Ecole Normale Supérieure de la rue d’Ulm, Paris, France. He then did his PhD in the laboratory of Prof. David Gray at The University of Edinburgh, UK. He was appointed in 2003 as the head of the Immune Regulation group at the Deutsches Rheuma-Forschungszentrum, a Leibniz Institute Berlin, Germany. Since 2015, he is Professor of Immunology at the Faculté de Médecine de l’Université Paris Descartes. He is AXA professor in Translation Immunology since 2016. In 2015, he received the prestigious European Research Council consolidator award, and GlaxoSmithKline Stiftung Wissenschaftspreise. His work investigates the role of B and T cells in autoimmune and infectious diseases. He discovered regulatory plasma cells, and demonstrated that endogenous self-antigens select thymic-derived autoreactive CD4+Foxp3+ T regulatory cells in a highly specific manner.

Focus

Our focus is the investigation of adaptive immunity (B cells and T cells) in autoimmune and infectious diseases. This currently includes 1) the characterization of effector and memory lymphocytes including novel plasma cell subsets, the molecular mechanisms controlling the pro- and anti-inflammatory functions of B cells, and 2) the development of cell-based therapies against immune-mediated inflammatory disorders using regulatory CD4 T cells and B cells. Our studies range from experimental models to human diseases, and are guided by the desire to perform fundamental discoveries that pave the way to innovative therapeutic solutions.

Introduction

The adaptive immune system is critical for host defense against pathogens. Primary genetic deficiencies resulting in the abnormal development of T or B lymphocytes are associated with an increased risk of fatal infections. Moreover, the vast majority of successful vaccines operate through the generation of memory lymphocytes including memory B cells, memory T cells, and long-lived plasma cells. Importantly, the adaptive immune system is also responsible for autoimmune and allergic disorders, which arise when it inappropriately reacts against self-antigens or components of the environment, respectively. The activation of such unwanted immune responses is normally controlled by the continuous activity of regulatory lymphocytes including CD4+Foxp3+ T regulatory cells, and regulatory plasma cells. Our group studies the antigen-recognition properties of these cells, their ontogeny, their life-span, and their mode of action in health and disease. Our long-term goal is to develop novel strategies to manipulate these cells therapeutically based on the knowledge gained from our basic studies. The Necker campus provides an exceptional environment to realize these studies, and translate them into clinical concepts.

Research objectives

Our goal is to understand how the adaptive immune system contributes to chronic diseases. Our hypothesis is that its activities are carried out by small groups of lymphocytes definable by their molecular properties. The identification of these cells is of paramount importance for immune monitoring, patient stratification, and the elaboration of novel treatment strategies.

- Our first objective is to discover so far unknown lymphocyte subsets. We have identified two novel subsets of regulatory plasmocytes. We are currently working at the characterization of these IL-10- and IL-35-producing plasmocytes, which are impaired in autoimmune disorders. This led us to pinpoint a subset of natural regulatory plasma cells distinctively characterized by the expression of LAG-3 and specialized in IL-10 production. We are currently in the process of characterizing additional subsets of regulatory plasma cells in mouse and man.

- Our second objective is to uncover the molecular mechanisms controlling the differentiation of effector lymphocyte subsets. An ongoing project is dealing with the identification of the molecular mechanisms governing the distinctive production of IL-6 by different B cell subsets upon activation, with the aim of identifying novels means to target this pro-inflammatory pathway.

- Our third objective is to translate our fundamental discoveries into novel therapies to improve the life of patients suffering from so far uncurable chronic diseases. This involves the development of novel cell-based therapy built on our current knowledge on regulatory CD4 T cells and B cells.

- Our fourth aim is to characterize the formation, maintenance, and reactivation of memory T and B cells in infectious (bacterial and viral diseases e.g. COVID-19) and chronic diseases.

5 main publications

1. Lino AC, Dang VD, Lampropoulou V, Welle A, Joedicke J, Pohar J, Simon Q, Thalmensi J, Baures A, Flühler V, Sakwa I, Stervbo U, Ries S, Jouneau L, Boudinot P, Tsubata T, Adachi T, Hutloff A, Dörner T, Zimber-Strobl U, de Vos AF, Dahlke K, Loh G, Korniotis S, Goosmann C, Weill JC, Reynaud CA, Kaufmann SHE, Walter J, Fillatreau S. 2018. LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells. Immunity. 49 :120-133.

2. Kieback, E., E. Hilgenberg, U. Stervbo, V. Lampropoulou, P. Shen, M. Bunse, Y. Jaimes, P. Boudinot, A. Radbruch, U. Klemm, A.A. Kühl, R. Liblau, N. Hoevelmeyer, S.M. Anderton, W. Uckert, and S. Fillatreau. 2016. Thymus-derived regulatory T cells are positively selected on natural self-antigen through TCR interactions of high functional avidity. Immunity. 44: 1114.

3. Shen, P., Roch, T., V. Lampropoulou, R.A. O’Connor, U. Stervbo, E. Hilgenberg, Y. Jaimes, C. Daridon, R. Lui, L. Jouneau, P. Boudinot, S. Ries, Y. Miyazaki, M.D. Leech, R.C. McPherson, S. Wirtz, M. Neurath, V.D. Dang, K. Hoehlig, E. Meinl, A. Grützkau, J.R. Grün, K. Horn, A.A. Kühl, T. Dörner, A. Bar-or, S.H.E. Kaufmann, S.M. Anderton, and S. Fillatreau. 2014. IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases. Nature. 507: 366.

4. Neves, P., V. Lampropoulou, E. Calderon-Gomez, T. Roch, U. Stervbo, P. Shen, A.A. Kuhl, C. Loddenkemper, M. Haury, S.A. Nedospasov, S.H. Kaufmann, U. Steinhoff, D.P. Calado, and S. Fillatreau. 2010. Signaling via the MyD88 adaptor protein in B cells suppresses protective immunity during Salmonella typhimurium infection. Immunity 33:777-790.

5. Fillatreau, S., C.H. Sweenie, M.J. McGeachy, D. Gray, and S.M. Anderton. 2002. B cells regulate autoimmunity by provision of IL-10. Nat Immunol 3:944-950.


 
30 dernières publications

2020

  • Malviya M, Saoudi A, Bauer J, Fillatreau S, Liblau R. 2019. Treatment of experimental autoimmune encephalomyelitis with engineered bi-specific Foxp3+ regulatory CD4+ T cells. J Autoimmun. 2020 doi: 10.1016/j.jaut.2020.102401. Epub 2020 Jan 13
  • 2019

  • Sato Y, Ries S, Stenzel W, Fillatreau S, Matuschewski K. 2019. The Liver-Stage Plasmodium Infection Is a Critical Checkpoint for Development of Experimental Cerebral Malaria. Front Immunol. 10:2554
  • Cerqueira C, Manfroi B, Fillatreau S. 2019. IL-10-producing regulatory B cells and plasmocytes: Molecular mechanisms and disease relevance. Semin Immunol. 44:101323
  • Cossarizza A, Chang HD, Radbruch A, Acs A, Adam D, Adam-Klages S, Agace WW, Aghaeepour N, Akdis M, Allez M, Almeida LN, Alvisi G, Anderson G, Andrä I, Annunziato F, Anselmo A, Bacher P, Baldari CT, Bari S, Barnaba V, Barros-Martins J, Battistini L, Bauer W, Baumgart S, Baumgarth N, Baumjohann D, Baying B, Bebawy M, Becher B, Beisker W, Benes V, Beyaert R, Blanco A, Boardman DA, Bogdan C, Borger JG, Borsellino G, Boulais PE, Bradford JA, Brenner D, Brinkman RR, Brooks AES, Busch DH, Büscher M, Bushnell TP, Calzetti F, Cameron G, Cammarata I, Cao X, Cardell SL, Casola S, Cassatella MA, Cavani A, Celada A, Chatenoud L, Chattopadhyay PK, Chow S, Christakou E, Čičin-Šain L, Clerici M, Colombo FS, Cook L, Cooke A, Cooper AM, Corbett AJ, Cosma A, Cosmi L, Coulie PG, Cumano A, Cvetkovic L, Dang VD, Dang-Heine C, Davey MS, Davies D, De Biasi S, Del Zotto G, Dela Cruz GV, Delacher M, Della Bella S, Dellabona P, Deniz G, Dessing M, Di Santo JP, Diefenbach A, Dieli F, Dolf A, Dörner T, Dress RJ, Dudziak D, Dustin M, Dutertre CA, Ebner F, Eckle SBG, Edinger M, Eede P, Ehrhardt GRA, Eich M, Engel P, Engelhardt B, Erdei A, Esser C, Everts B, Evrard M, Falk CS, Fehniger TA, Felipo-Benavent M, Ferry H, Feuerer M, Filby A, Filkor K, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frehse B, Frenette PS, Frischbutter S, Fritzsche W, Galbraith DW, Gangaev A, Garbi N, Gaudilliere B, Gazzinelli RT, Geginat J, Gerner W, Gherardin NA, Ghoreschi K, Gibellini L, Ginhoux F, Goda K, Godfrey DI, Goettlinger C, González-Navajas JM, Goodyear CS, Gori A, Grogan JL, Grummitt D, Grützkau A, Haftmann C, Hahn J, Hammad H, Hämmerling G, Hansmann L, Hansson G, Harpur CM, Hartmann S, Hauser A, Hauser AE, Haviland DL, Hedley D, Hernández DC, Herrera G, Herrmann M, Hess C, Höfer T, Hoffmann P, Hogquist K, Holland T, Höllt T, Holmdahl R, Hombrink P, Houston JP, Hoyer BF, Huang B, Huang FP, Huber JE, Huehn J, Hundemer M, Hunter CA, Hwang WYK, Iannone A, Ingelfinger F, Ivison SM, Jäck HM, Jani PK, Jávega B, Jonjic S, Kaiser T, Kalina T, Kamradt T, Kaufmann SHE, Keller B, Ketelaars SLC, Khalilnezhad A, Khan S, Kisielow J, Klenerman P, Knopf J, Koay HF, Kobow K, Kolls JK, Kong WT, Kopf M, Korn T, Kriegsmann K, Kristyanto H, Kroneis T, Krueger A, Kühne J, Kukat C, Kunkel D, Kunze-Schumacher H, Kurosaki T, Kurts C, Kvistborg P, Kwok I, Landry J, Lantz O, Lanuti P, LaRosa F, Lehuen A, LeibundGut-Landmann S, Leipold MD, Leung LYT, Levings MK, Lino AC, Liotta F, Litwin V, Liu Y, Ljunggren HG, Lohoff M, Lombardi G, Lopez L, López-Botet M, Lovett-Racke AE, Lubberts E, Luche H, Ludewig B, Lugli E, Lunemann S, Maecker HT, Maggi L, Maguire O, Mair F, Mair KH, Mantovani A, Manz RA, Marshall AJ, Martínez-Romero A, Martrus G, Marventano I, Maslinski W, Matarese G, Mattioli AV, Maueröder C, Mazzoni A, McCluskey J, McGrath M, McGuire HM, McInnes IB, Mei HE, Melchers F, Melzer S, Mielenz D, Miller SD, Mills KHG, Minderman H, Mjösberg J, Moore J, Moran B, Moretta L, Mosmann TR, Müller S, Multhoff G, Muñoz LE, Münz C, Nakayama T, Nasi M, Neumann K, Ng LG, Niedobitek A, Nourshargh S, Núñez G, O'Connor JE, Ochel A, Oja A, Ordonez D, Orfao A, Orlowski-Oliver E, Ouyang W, Oxenius A, Palankar R, Panse I, Pattanapanyasat K, Paulsen M, Pavlinic D, Penter L, Peterson P, Peth C, Petriz J, Piancone F, Pickl WF, Piconese S, Pinti M, Pockley AG, Podolska MJ, Poon Z, Pracht K, Prinz I, Pucillo CEM, Quataert SA, Quatrini L, Quinn KM, Radbruch H, Radstake TRDJ, Rahmig S, Rahn HP, Rajwa B, Ravichandran G, Raz Y, Rebhahn JA, Recktenwald D, Reimer D, Reis E Sousa C, Remmerswaal EBM, Richter L, Rico LG, Riddell A, Rieger AM, Robinson JP, Romagnani C, Rubartelli A, Ruland J, Saalmüller A, Saeys Y, Saito T, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sandrock I, Santoni A, Sanz RB, Saresella M, Sautes-Fridman C, Sawitzki B, Schadt L, Scheffold A, Scherer HU, Schiemann M, Schildberg FA, Schimisky E, Schlitzer A, Schlosser J, Schmid S, Schmitt S, Schober K, Schraivogel D, Schuh W, Schüler T, Schulte R, Schulz AR, Schulz SR, Scottá C, Scott-Algara D, Sester DP, Shankey TV, Silva-Santos B, Simon AK, Sitnik KM, Sozzani S, Speiser DE, Spidlen J, Stahlberg A, Stall AM, Stanley N, Stark R, Stehle C, Steinmetz T, Stockinger H, Takahama Y, Takeda K, Tan L, Tárnok A, Tiegs G, Toldi G, Tornack J, Traggiai E, Trebak M, Tree TIM, Trotter J, Trowsdale J, Tsoumakidou M, Ulrich H, Urbanczyk S, van de Veen W, van den Broek M, van der Pol E, Van Gassen S, Van Isterdael G, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Borstel A, von Volkmann K, Waisman A, Walker RV, Wallace PK, Wang SA, Wang XM, Ward MD, Ward-Hartstonge KA, Warnatz K, Warnes G, Warth S, Waskow C, Watson JV, Watzl C, Wegener L, Weisenburger T, Wiedemann A, Wienands J, Wilharm A, Wilkinson RJ, Willimsky G, Wing JB, Winkelmann R, Winkler TH, Wirz OF, Wong A, Wurst P, Yang JHM, Yang J, Yazdanbakhsh M, Yu L, Yue A, Zhang H, Zhao Y, Ziegler SM, Zielinski C, Zimmermann J, Zychlinsky A. 2019. Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Eur J Immunol. 49:1457-1973
  • Fillatreau S. 2019. Regulatory functions of B cells and regulatory plasma cells. Biomed J. 42:233-242
  • Thi Cuc B, Pohar J, Fillatreau S. 2019. Understanding regulatory B cells in autoimmune diseases: the case of multiple sclerosis. Curr Opin Immunol. 61:26-32
  • Simon Q, Fillatreau S. 2019. Identification of natural regulatory plasma cells and their role in physiopathology. Med Sci (Paris). 35: 305-307
  • 2018

  • Magadan S, Jouneau L, Puelma Touzel M, Marillet S, Chara W, Six A, Quillet E, Mora T, Walczak AM, Cazals F, Sunyer O, Fillatreau S, Boudinot P. 2018. Origin of Public Memory B Cell Clones in Fish After Antiviral Vaccination. Front Immunol. 9:2115.
  • Fillatreau S. 2018. Natural regulatory plasma cells. Curr Opin Immunol. 55:62-66.
  • Pohar J, Simon Q, Fillatreau S. 2018. Antigen-Specificity in the Thymic Development and Peripheral Activity of CD4+FOXP3+ T Regulatory Cells. Front Immunol. 9:1701.
  • Lino AC, Dang VD, Lampropoulou V, Welle A, Joedicke J, Pohar J, Simon Q, Thalmensi J, Baures A, Flühler V, Sakwa I, Stervbo U, Ries S, Jouneau L, Boudinot P, Tsubata T, Adachi T, Hutloff A, Dörner T, Zimber-Strobl U, de Vos AF, Dahlke K, Loh G, Korniotis S, Goosmann C, Weill JC, Reynaud CA, Kaufmann SHE, Walter J, Fillatreau S. 2018. LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells. Immunity. 49 :120-133.
  • Meng X, Grötsch B, Luo Y, Knaup KX, Wiesener MS, Chen XX, Jantsch J, Fillatreau S, Schett G, Bozec A. 2018. Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease. Nat Commun. 9 :251.
  • Bénard A, Sakwa I, Schierloh P, Colom A, Mercier I, Tailleux L, Jouneau L, Boudinot P, Al-Saati T, Lang R, Rehwinkel J, Loxton AG, Kaufmann SHE, Anton-Leberre V, O'Garra A, Sasiain MDC, Gicquel B, Fillatreau S*, Neyrolles O*, Hudrisier D*. 2018. B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis. Am J Respir Crit Care Med. 197 :801-813. * these authors contributed equally.
  • 2017

  • Cossarizza A, Chang HD, Radbruch A, Akdis M, Andrä I, Annunziato F, Bacher P, Barnaba V, Battistini L, Bauer WM, Baumgart S, Becher B, Beisker W, Berek C, Blanco A, Borsellino G, Boulais PE, Brinkman RR, Büscher M, Busch DH, Bushnell TP, Cao X, Cavani A, Chattopadhyay PK, Cheng Q, Chow S, Clerici M, Cooke A, Cosma A, Cosmi L, Cumano A, Dang VD, Davies D, De Biasi S, Del Zotto G, Della Bella S, Dellabona P, Deniz G, Dessing M, Diefenbach A, Di Santo J, Dieli F, Dolf A, Donnenberg VS, Dörner T, Ehrhardt GRA, Endl E, Engel P, Engelhardt B, Esser C, Everts B, Dreher A, Falk CS, Fehniger TA, Filby A, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frenette PS, Galbraith D, Garbi N, García-Godoy MD, Geginat J, Ghoreschi K, Gibellini L, Goettlinger C, Goodyear CS, Gori A, Grogan J, Gross M, Grützkau A, Grummitt D, Hahn J, Hammer Q, Hauser AE, Haviland DL, Hedley D, Herrera G, Herrmann M, Hiepe F, Holland T, Hombrink P, Houston JP, Hoyer BF, Huang B, Hunter CA, Iannone A, Jäck HM, Jávega B, Jonjic S, Juelke K, Jung S, Kaiser T, Kalina T, Keller B, Khan S, Kienhöfer D, Kroneis T, Kunkel D, Kurts C, Kvistborg P, Lannigan J, Lantz O, Larbi A, LeibundGut-Landmann S, Leipold MD, Levings MK, Litwin V, Liu Y, Lohoff M, Lombardi G, Lopez L, Lovett-Racke A, Lubberts E, Ludewig B, Lugli E, Maecker HT, Martrus G, Matarese G, Maueröder C, McGrath M, McInnes I, Mei HE, Melchers F, Melzer S, Mielenz D, Mills K, Mirrer D, Mjösberg J, Moore J, Moran B, Moretta A, Moretta L, Mosmann TR, Müller S, Müller W, Münz C, Multhoff G, Munoz LE, Murphy KM, Nakayama T, Nasi M, Neudörfl C, Nolan J, Nourshargh S, O'Connor JE, Ouyang W, Oxenius A, Palankar R, Panse I, Peterson P, Peth C, Petriz J, Philips D, Pickl W, Piconese S, Pinti M, Pockley AG, Podolska MJ, Pucillo C, Quataert SA, Radstake TRDJ, Rajwa B, Rebhahn JA, Recktenwald D, Remmerswaal EBM, Rezvani K, Rico LG, Robinson JP, Romagnani C, Rubartelli A, Ruckert B, Ruland J, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sawitzki B, Scheffold A, Schiemann M, Schildberg F, Schimisky E, Schmid SA, Schmitt S, Schober K, Schüler T, Schulz AR, Schumacher T, Scotta C, Shankey TV, Shemer A, Simon AK, Spidlen J, Stall AM, Stark R, Stehle C, Stein M, Steinmetz T, Stockinger H, Takahama Y, Tarnok A, Tian Z, Toldi G, Tornack J, Traggiai E, Trotter J, Ulrich H, van der Braber M, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Volkmann K, Waisman A, Walker R, Ward MD, Warnatz K, Warth S, Watson JV, Watzl C, Wegener L, Wiedemann A, Wienands J, Willimsky G, Wing J, Wurst P, Yu L, Yue A, Zhang Q, Zhao Y, Ziegler S, Zimmermann J. 2017. Guidelines for the use of flow cytometry and cell sorting in immunological studies. Eur J Immunol. 47:1584-1797.
  • Zivéri, J., F. Tros, I.C. Guerrara, C. Chhuon, M. Audry, M. Dupuis, M. Barel, S. Korniotis, S. Fillatreau, L. Gales, E. Cahoreau, A. Charbit. 2017. Fructose-1,6-bisphosphate aldolase, a ubiquitous metabolic enzyme with regulatory functions in pathogenic Francisella. Nat Commun. 8:853.
  • Fleischer S, Ries S, Shen P, Lheritier A, Cazals F, Burmester GR, Dörner T, Fillatreau S. 2017. Anti-interleukin-6 signalling therapy rebalances the disrupted cytokine production of B cells from patients with active rheumatoid arthritis. Eur J Immunol. doi: 10.1002/eji.201747191.
  • Fillatreau, S. 2017. B cells and their cytokine activities - Implications in human diseases. Clinical Immunology. In press.
  • 2016

  • Fillatreau S. Regulatory roles of B cells in infectious diseases. Clin Exp Rheumatol. 2016 Jul-Aug;34(4 Suppl 98):1-5.
  • Korniotis S, Gras C, Letscher H, Montandon R, Mégret J, Siegert S, Ezine S, Fallon PG, Luther SA, Fillatreau S, Zavala F. Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells. Nat Commun. 2016 Jul 11;7:12134.
  • Kieback E, Hilgenberg E, Stervbo U, Lampropoulou V, Shen P, Bunse M, Jaimes Y, Boudinot P, Radbruch A, Klemm U, Kühl AA, Liblau R, Hoevelmeyer N, Anderton SM, Uckert W, Fillatreau S. Thymus-Derived Regulatory T Cells Are Positively Selected on Natural Self-Antigen through Cognate Interactions of High Functional Avidity. Immunity. 2016 May 17;44(5):1114-26.
  • Hojyo S, Sarkander J, Männe C, Mursell M, Hanazawa A, Zimmel D, Zhu J, Paul WE, Fillatreau S, Löhning M, Radbruch A, Tokoyoda K. B Cells Negatively Regulate the Establishment of CD49b(+)T-bet(+) Resting Memory T Helper Cells in the Bone Marrow. Front Immunol. 2016 Feb 2;7:26. doi: 10.3389/fimmu.2016.00026. eCollection 2016.
  • Lino AC, Dörner T, Bar-Or A, Fillatreau S. Cytokine-producing B cells: a translational view on their roles in human and mouse autoimmune diseases. Immunol Rev. 2016 Jan;269(1):130-44. doi: 10.1111/imr.12374.
  • 2015

  • Li R, Rezk A, Miyazaki Y, Hilgenberg E, Touil H, Shen P, Moore CS, Michel L, Althekair F, Rajasekharan S, Gommerman JL, Prat A, Fillatreau S, Bar-Or A; Canadian B cells in MS Team. Proinflammatory GM-CSF-producing B cells in multiple sclerosis and B cell depletion therapy. Sci Transl Med. 2015 Oct 21;7(310)
  • Anderton SM, Fillatreau S. Editorial overview: Immunomodulation: New insights for future treatments. Curr Opin Pharmacol. 2015 Aug;23:vii-ix. doi: 10.1016/j.coph.2015.06.005.
  • Shen P, Fillatreau S. Suppressive functions of B cells in infectious diseases. Int Immunol. 2015 Oct;27(10):513-9.
  • Shen P, Fillatreau S. Antibody-independent functions of B cells: a focus on cytokines. Nat Rev Immunol. 2015 Jul;15(7):441-51. doi: 10.1038/nri3857. Review.
  • Fillatreau S. Regulatory plasma cells. Curr Opin Pharmacol. 2015 Aug;23:1-5.
  • Fillatreau S. Pathogenic functions of B cells in autoimmune diseases: IFN-γ production joins the criminal gang. Eur J Immunol. 2015 Apr;45(4):966-70.
  • 2014

  • Sieber J, Daridon C, Fleischer SJ, Fleischer V, Hiepe F, Alexander T, Heine G, Burmester GR, Fillatreau S, Dörner T. Active systemic lupus erythematosus is associated with a reduced cytokine production by B cells in response to TLR9 stimulation. Arthritis Res Ther. 2014 Nov 11;16(6):477.
  • Grötsch B, Brachs S, Lang C, Luther J, Derer A, Schlötzer-Schrehardt U, Bozec A, Fillatreau S, Berberich I, Hobeika E, Reth M, Wagner EF, Schett G, Mielenz D, David JP. The AP-1 transcription factor Fra1 inhibits follicular B cell differentiation into plasma cells. J Exp Med. 2014 Oct 20;211(11):2199-212. doi: 10.1084/jem.20130795. Erratum in: J Exp Med. 2014 Oct 20;211(11):223.
  • Kieback E, Hilgenberg E, Fillatreau S. A method for the generation of TCR retrogenic mice. Methods Mol Biol. 2014;1193:117-26.
  • Miyazaki Y, Li R, Rezk A, Misirliyan H, Moore C, Farooqi N, Solis M, Goiry LG, de Faria Junior O, Dang VD, Colman D, Dhaunchak AS, Antel J, Gommerman J, Prat A, Fillatreau S, Bar-Or A; CIHR/MSSC New Emerging Team Grant in Clinical Autoimmunity.; MSSRF Canadian B cells in MS Team. A novel microRNA-132-sirtuin-1 axis underlies aberrant B-cell cytokine regulation in patients with relapsing-remitting multiple sclerosis [corrected]. PLoS One. 2014 Aug 19;9(8):e105421. doi: 10.1371/journal.pone.0105421. Erratum in: PLoS One. 2014;9(9):e109041.
  • Moura-Alves P, Faé K, Houthuys E, Dorhoi A, Kreuchwig A, Furkert J, Barison N, Diehl A, Munder A, Constant P, Skrahina T, Guhlich-Bornhof U, Klemm M, Koehler AB, Bandermann S, Goosmann C, Mollenkopf HJ, Hurwitz R, Brinkmann V, Fillatreau S, Daffe M, Tümmler B, Kolbe M, Oschkinat H, Krause G, Kaufmann SH. AhR sensing of bacterial pigments regulates antibacterial defence. Nature. 2014 Aug 28;512(7515):387-92.
  • Calderón-Gómez E, Fillatreau S. Utilization of a lentiviral system for the generation of B cells with regulatory properties. Methods Mol Biol. 2014;1190:105-13.
  • Hilgenberg E, Shen P, Dang VD, Ries S, Sakwa I, Fillatreau S. Interleukin-10-producing B cells and the regulation of immunity. Curr Top Microbiol Immunol. 2014;380:69-92.
  • Fillatreau S. Monocyte-derived dendritic cells identified as booster of T follicular helper cell differentiation. EMBO Mol Med. 2014 May 1;6(5):574-6
  • Fillatreau S. Sweetened antibodies against humoral autoimmunity: sialylated antibodies are required for IVIg-mediated therapy. Eur J Immunol. 2014 May;44(5):1276-80.
  • Raftery MJ, Wolter E, Fillatreau S, Meisel H, Kaufmann SH, Schönrich G. NKT cells determine titer and subtype profile of virus-specific IgG antibodies during herpes simplex virus Infection. J Immunol. 2014 May 1;192(9):4294-302.
  • Weber M, Stein P, Prüfer S, Rudolph B, Kreft A, Schmitt E, Bopp T, Roers A, Schild H, Fillatreau S, Radsak MP. Donor and host B cell-derived IL-10 contributes to suppression of graft-versus-host disease. Eur J Immunol. 2014 Jun;44(6):1857-65
  • Dang VD, Hilgenberg E, Ries S, Shen P, Fillatreau S. From the regulatory functions of B cells to the identification of cytokine-producing plasma cell subsets. Curr Opin Immunol. 2014 Jun;28:77-83.
  • Ries S, Hilgenberg E, Lampropoulou V, Shen P, Dang VD, Wilantri S, Sakwa I, Fillatreau S. B-type suppression: a role played by "regulatory B cells" or "regulatory plasma cells"? Eur J Immunol. 2014 May;44(5):1251-7.
  • Shen P, Roch T, Lampropoulou V, O'Connor RA, Stervbo U, Hilgenberg E, Ries S, Dang VD, Jaimes Y, Daridon C, Li R, Jouneau L, Boudinot P, Wilantri S, Sakwa I, Miyazaki Y, Leech MD, McPherson RC, Wirtz S, Neurath M, Hoehlig K, Meinl E, Grützkau A, Grün JR, Horn K, Kühl AA, Dörner T, Bar-Or A, Kaufmann SH, Anderton SM, Fillatreau S. IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases. Nature. 2014 Mar 20;507(7492):366-70.
  • 2013

  • Mensen A, Ochs C, Stroux A, Wittenbecher F, Szyska M, Imberti L, Fillatreau S, Uharek L, Arnold R, Dörken B, Thiel A, Scheibenbogen C, Na IK. Utilization of TREC and KREC quantification for the monitoring of early T- and B-cell neogenesis in adult patients after allogeneic hematopoietic stem cell transplantation. J Transl Med. 2013 Aug 14;11:188
  • Fillatreau S, Six A, Magadan S, Castro R, Sunyer JO, Boudinot P. The astonishing diversity of Ig classes and B cell repertoires in teleost fish. Front Immunol. 2013 Feb 13;4:28. doi: 10.3389/fimmu.2013.00028
  • Castro R, Jouneau L, Pham HP, Bouchez O, Giudicelli V, Lefranc MP, Quillet E, Benmansour A, Cazals F, Six A, Fillatreau S, Sunyer O, Boudinot P. Teleost fish mount complex clonal IgM and IgT responses in spleen upon systemic viral infection. PLoS Pathog. 2013 Jan;9(1):e1003098. doi: 10.1371/journal.ppat.1003098.
  • Shen P, Lampropoulou V, Stervbo U, Hilgenberg E, Ries S, Mecqinion A, Fillatreau S. Intrinsic Toll-like receptor signalling drives regulatory function in B cells. Front Biosci (Elite Ed). 2013 Jan 1;5:78-86. Review.
  • Fillatreau S. Cytokine-producing B cells as regulators of pathogenic and protective immune responses. Ann Rheum Dis. 2013 Apr;72 Suppl 2:ii80-4
  • Chercheur statutaire
    Mohamed El Behi
    Chercheur
    +33 (0)1 40 61 53 21
    Simon Fillatreau
    Chercheur hospitalo-Universitaire
    +33(0)1 40 61 53 20
    ITA non statutaire
    Marylin Harinquet
    Ingénieur(e) en techniques biologiques
    +33 (0)1 40 61 53 21
    Mélanie Hery
    Ingénieur(e) en techniques biologiques
    Valentine Pottez-Jouatte
    Ingénieur
    Post-doctorant
    Helena Costa Verdera
    Post-doctorant(e)
    Benoit Manfroi
    Post-doctorant(e)
    +33 (0)1 40 61 53 21
    Doctorant
    Cuc Bui Thi
    Doctorant(e)
    +33 (0)1 40 61 53 21
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    Parrain(s)
    S.A.R. la Princesse Caroline de Hanovre qui, à travers la Fondation Princesse Grace, soutient déjà la recherche medicale et tout ce qui contribue à soulager les enfants malades en France et dans le monde, a accepté de s'engager à nos cotés pour que ce centre de medecine moleculaire, tourné entre autres vers les pathologies des enfants, prenne de vitesse les maladies et continue à relever les defis actuels.

    INEM - Organigramme