Elizabeth Macintyre, M.D-PhD FRCP/Path is Professor of Hematology at the Paris Descartes Medical School. She trained in internal Medicine and clinical and laboratory Hematology in the UK (Newcastle and UCL), did her PhD in Paris (St. Louis) and her post-doctoral fellowship in Harvard. She joined the Medical Faculty at Descartes in 1992 and has headed the Hematology Laboratory and the integrated Hematopathology Cancer programmes since 1999 and 2007, respectively.
Vahid Asnafi, M.D-PhD studied Medicine at Paris Descartes before specializing in laboratory Hematology. He obtained his PhD at Descartes in 2003 before doing his post-doctoral studies with Pierre Ferrier at CIML, Marseille. Returning to Necker in 2005, he was appointed full Professor of Hematology in 2012 and now heads the Onco-Hématology laboratory and well as co-directing the "Normal and Pathological Lymphoid Differentiation Team" at INEM
We study molecular mechanisms controlling TCR VDJ rearrangements during human T-cell ontogeny and their implication in (epi)genetic deregulation in T-lymphoid oncogenesis, in order to develop targeted therapeutics for leukemia and lymphoma.
Our research essentially involves analysis of the mechanisms controlling human T lymphoid ontogeny and oncogenic transformation in immature T lymphoid malignancies, particularly T-cell lymphoblastic acute leukemias (T-ALL) and lymphomas (T-LBL).
T-ALLs are malignant clonal proliferations arrested at specific stages of thymic differentiation. Oncogenic deregulation and physiological T lymphopoiesis, including the mechanisms regulating the somatic rearrangements leading to assembly of a T Cell Receptor (TCR), are intimately linked, which implies the contribution of physiological proliferative/apoptotic signals to the oncogenic process.
We have developed cellular and molecular characterisation of lymphoid malignancies in close collaboration with clinical cooperative and fundamental cognitive research groups in order to ensure optimal human tissue resource management and valorisation. All research projects are based on the principal that unravelling oncogenic pathways with an aim to improving treatment requires in-depth understanding of normal development of the system which has undergone deregulated tissue homeostasis.
These studies are possible due to close collaboration with the adult (Group for Research in Adult ALL or GRAALL and Lymphoma Study Association or LYSA) and pediatric (Société Française des Cancers de l’Enfant or SFCE Leukemia and Lymphoma committees) clinical cooperative groups, and with a variety of European networks, such as the EuroFLOW, EuroMRD, EuroClonality and Blueprint consortia.
Cellular and molecular characterization of lymphoid malignancies, with particular emphasis on T lymphoid oncogenesis: