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Mardi 5 décembre 2023
Just Published: The AMPK-Sirtuin 1-YAP axis is regulated by fluid flow intensity and controls autophagy flux in kidney epithelial cells by Aurore Claude-Taupin
In their recently published paper in Nature Communications, Aurore Claude-Taupin et al. explore the critical role of shear stress, a known regulator of renal function, and its dysregulation in various kidney diseases.

Building on prior research highlighting the significance of primary cilium-dependent autophagy in kidney epithelial cells' response to fluid flow, a new dimension has emerged.

Key Insights
  • Nuclear YAP/TAZ's involvement in negatively regulating autophagy flux in response to fluid flow in kidney epithelial cells.
  • This crosstalk is facilitated by primary cilium-dependent activation of AMPK and SIRT1, independently of the Hippo pathway.
  • Validation of the YAP/TAZ-autophagy molecular dialog in in vivo models including a zebrafish model of kidney development and a mouse model of unilateral ureteral obstruction.
  • In vitro assay replicating accelerated flow in early chronic kidney disease (CKD) stages activates YAP, leading to a primary cilium-dependent inhibition of autophagic flux.
  • Confirmation of the YAP/autophagy relationship in renal biopsies from patients with diabetic kidney disease (DKD), the primary cause of CKD.
The findings shed light on the pivotal roles of YAP/TAZ and autophagy in translating fluid flow into cellular and physiological responses, providing valuable insights into the molecular mechanisms of kidney diseases.

Read the full article here:

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S.A.R. la Princesse Caroline de Hanovre qui, à travers la Fondation Princesse Grace, soutient déjà la recherche medicale et tout ce qui contribue à soulager les enfants malades en France et dans le monde, a accepté de s'engager à nos cotés pour que ce centre de medecine moleculaire, tourné entre autres vers les pathologies des enfants, prenne de vitesse les maladies et continue à relever les defis actuels.

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