Bienvenu(e) sur le site de l'Institut Necker Enfants Malades
Lundi 24 avril 2023
Identification of AKT-FoxO1 as an on/off gate for marginal zone B cell development

The team of Simon Fillatreau identified in a collaborative work with the team of Dr. Nadine Hövelmeyer (Mainz University, Germany) the chief role of the AKT-FoxO1 signaling axis in the formation of mouse and human marginal zone B cells, which are involved in host defense against encapsulated bacteria (Cell Reports, doi: 10.1016/j.celrep.2023.112378). Remarkably, AKT signaling also conferred B cells with increased innate function, a distinctive functional property of marginal zone B cells, thus linking the signals controlling the development of these cells to their function. Furthermore, they identified CD148 as a receptor present at higher level on the surface of marginal zone B cells in mice and humans, compared to other B cell subsets, and whose expression in B cells is controlled by AKT signaling intensity, potentially providing a key to evaluate AKT signaling and track innate B cells.


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S.A.R. la Princesse Caroline de Hanovre qui, à travers la Fondation Princesse Grace, soutient déjà la recherche medicale et tout ce qui contribue à soulager les enfants malades en France et dans le monde, a accepté de s'engager à nos cotés pour que ce centre de medecine moleculaire, tourné entre autres vers les pathologies des enfants, prenne de vitesse les maladies et continue à relever les defis actuels.

INEM - Organigramme