Welcome on the Necker-Enfants Malades Institute website
Friday 19 of November, 2021
Glomerular endothelial cell senescence drives age-related kidney disease through PAI-1

A study conducted by the team of Fabiola Terzi has just been published in EMBO Molecular Medicine :
(https://pubmed-ncbi-nlm-nih-gov.proxy.insermbiblio.inist.fr/34725920/)

Kidneys develop lesions with age, and in particular glomerulosclerosis. The molecular mechanisms involved in the deterioration process are still unclear. By combining experimental models of aging, transgenic mice and molecular studies, the Terzi’s team has uncovered an unexpected role for glomerular endothelial cells during aging. In particular, they elucidated a detrimental cross-talk between senescent endothelial cells and podocytes, through PAI-1. More importantly, they identified PAI-1 as a promising biomarker of kidney dysfunction in allografts from elderly donors. Therefore, PAI-1 appears as a prognostic marker as well as a therapeutic target to prolong renal survival during aging.

Address

Notice: Undefined variable: contact_addr in /homepages/40/d483507699/htdocs/location.php on line 21
Support(s)
HRH Princess Caroline of Hanover, who through the Princess Grace Foundation, already supports medical research and anything that helps to relieve the sick children in France and around the world, has agreed to commit to our side so that our Center of Molecular medicine continues to meet the current challenges and fight diseases, and in particular the ones affecting children.

INEM - Organigramme