Seminar topic: Loss of MTPAP disrupts mtRNA processing causing upregulation of type I interferon signaling

“I am focused on cellular biology in the context of neurological disease. I did my PhD at Paris Brain Institute with Dr Frédéric Darios on the implication of lysosomal storage disorder in Hereditary Spastic Paraplegia. In 2023, I joined Institute Imagine to work with Dr. Alice Lepelley on the role of mitochondrial nucleic acid leakage in the development of Interferonopathies. 
The project that I will present deals with how mutations of MTPAP lead to mitochondrial dysfunctions but not only. Indeed, we observed that it triggers an activation of the immune sensing and my objective was to reconstitute the series of event that connect loss of MTPAP function to immune signaling.”

Please join us to discuss and exchange ideas regarding Alexandre’s research!

____________

What is PPS?

A cross-institute seminar series where postdocs are invited to present their work in an institute other than their own. While the speakers are postdocs, the seminars are open to the entire institute. This creates a unique opportunity for postdocs to showcase their work to a broad audience, foster scientific exchange, and potentially spark future collaborations or even find their next lab.

Launched in 2023 with just six institutes, the initiative has grown remarkably — this year, 15 institutes take part in it and extend the seminar series beyond the Paris region. Thanks to this expanding network, the PPS has become a vibrant platform for postdocs to share their research and discover scientific communities across institutes.
_____________

Image