Bienvenu(e) sur le site de l'Institut Necker Enfants Malades
Mardi 12 septembre 2023
Just published in Immunity: SARS-CoV-2 Omicron BA.1 breakthrough infection drives late remodeling of the memory B cell repertoire in vaccinated individuals

The team of Matthieu Mahévas and Pascal Chappert have been following up on their recent work on B cell responses in the context of SARS-CoV-2 infection and mRNA vaccination. Studying memory B cells and plasma cells post SARS-CoV-2 Omicron BA.1 breakthrough infection in individuals previously vaccinated with three doses of the COVID-19 mRNA vaccine, they show clear signs of antigen imprinting from the Hu-1 Spike encoded in the vaccine. However, the diversity of the vaccine-induced memory B cell repertoire and the possibility to further mature such memory through clonal hierarchy reorganization and additional rounds of affinity maturation combined to induce an adaptation to the new viral strain and a marked improvement in overall neutralizing breadth and potency post-infection. These findings have fundamental implications for the design of future vaccination booster strategies.


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S.A.R. la Princesse Caroline de Hanovre qui, à travers la Fondation Princesse Grace, soutient déjà la recherche medicale et tout ce qui contribue à soulager les enfants malades en France et dans le monde, a accepté de s'engager à nos cotés pour que ce centre de medecine moleculaire, tourné entre autres vers les pathologies des enfants, prenne de vitesse les maladies et continue à relever les defis actuels.

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