Presentation topic: Rat Duchenne muscular dystrophy models to decipher disease mechanisms and preclinical studies
 

I completed my Ph.D. in molecular and cellular developmental biology at the Mount Sinai School of Medicine (New York) in the laboratory of Prof. David Sassoon, where I studied the genetic regulation of skeletal muscle development and differentiation. I then pursued postdoctoral training at the Institut Pasteur in Paris in the laboratory of Prof. Margaret Buckingham, focusing on the molecular control of skeletal muscle development and muscle stem cell biology. I was recruited by INSERM in 2000 and became an INSERM Research Director in 2006, after being awarded an INSERM AVENIR program that allowed me to establish my own independent research group at the Myology Institute (Pitié-Salpétrière, Paris). 

Since 2015, I am a Full Professor (PU-PH) at Université Paris-Est Créteil and serve as Vice-Dean for Research of the Faculty of Medicine and Health. I lead the research team "Muscle Stem cells and therapies" at the IMRB (Inserm U955) and head the AFM-Téléthon strategic research pole Translamuscle, coordinating large multidisciplinary programs dedicated to muscle stem cells, neuromuscular diseases, preclinical modeling and development of innovative therapies. My research focuses on the regulation of skeletal muscle stem cell during development, regeneration, and disease, with particular emphasis on PAX3/7 transcription factors, stem cell quiescence, and translational approaches for Duchenne muscular dystrophy. My work has been supported by major national and international funding agencies, and has resulted in over 140 peer-reviewed publications in leading journals. Through both my scientific and institutional roles, I am actively involved in shaping the fields of muscle biology, regenerative medicine, and translational neuromuscular research at the international level.