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Christopher Carl Goodnow

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Christopher C Goodnow holds The Bill and Patricia Ritchie Foundation Chair as Head of the Immunogenomics Laboratory at the Garvan Institute of Medical Research, and is Professor in the Cellular Genomics Futures Institute and School of Biomedical Sciences at UNSW Sydney. He trained in veterinary medicine and surgery, immunochemistry, and immunology at Sydney University and in DNA technology and molecular immunology at Stanford University.

Brendan Manning

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Brendan Manning is a Professor and Chair in the Department of Molecular Metabolism at the Harvard T.H. Chan School of Public Health (HSPH), with additional faculty affiliations in the Department of Cell Biology at Harvard Medical School and the Dana-Farber/Harvard Cancer Center. Prof. Manning received his B.S. from the University of Massachusetts, Amherst and his Ph.D. from Yale University. Following postdoctoral research at Harvard Medical School, he joined the faculty of the then newly established Department of Genetics and Complex Diseases at HSPH (renamed Molecular Metabolism in 2019).

Meryem Baghdadi

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Meryem B. Baghdadi is a researcher in the field of stem cell and development biology and has made significant contributions to the understanding of stem cell niches and their regulation in both homeostasis and disease contexts.

Auteurs
Andrieu GP, Simonin M, Cabannes-Hamy A, Lengliné E, Marçais A, Théron A, Huré G, Doss J, Nemazanyy I, Dourthe MÉ, Boissel N, Dombret H, Rousselot P, Hermine O, Asnafi V

A metabolic synthetic lethality of phosphoinositide 3-kinase-driven cancer

Date revue
Doi
10.1038/s41467-025-57225-7
Revue
Nat Commun

Nouvelle publication dans Nature Communications : Cibler les vulnérabilités métaboliques dans les leucémies PI3K-dépendantes

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La voie de signalisation PI3K (phosphoinositide 3-kinase) est un moteur clé de la plasticité métabolique des tumeurs agressives, leur permettant de s’adapter au microenvironnement et de résister aux traitements. Cibler efficacement ces cancers reste cependant un défi majeur. 

Philippe Sansonetti

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Philippe Sansonetti, MD, trained in infectious diseases in Paris and in bacterial genetics at Institut Pasteur, Paris, then at the Walter Reed Army Institute of Research as a post-doctoral scientist. He is currently Emeritus Professor at Institut Pasteur and at the Collège de France where he has been lecturing for 12 years at the interface between basic microbiology and emerging infectious diseases.

Auteurs
Rivagorda M, Romeo-Guitart D, Blanchet V, Mailliet F, Boitez V, Barry N, Milunov D, Siopi E, Goudin N, Moriceau S, Guerrera C, Leibovici M, Saha S, Codogno P, Morselli E, Morel E, Armand AS, Oury F

A primary cilia-autophagy axis in hippocampal neurons is essential to maintain cognitive resilience

Date revue
Doi
10.1038/s43587-024-00791-0
Revue
Nat Aging