Chantal Desdouets leads the "Genomic Instability, Metabolism, Immunity and Liver Tumorigenesis" team at the Centre Recherche des Cordeliers in Paris. A world-renowned expert, Dr Desdouets's research focuses on the intricate processes of hepatic division and polyploidization in both healthy and diseased states. Her team is particularly investigating the link between obesity associated with overfeeding and/or sedentary lifestyles and metabolic dysfunction-associated steatotic liver disease (MASLD), a spectrum that includes metabolic dysfunction-associated steatohepatitis (MASH). Given the rising morbidity and mortality from hepatocellular carcinoma (HCC) mirroring the increasing prevalence of MASLD, her team aims to elucidate how polyploidy, DNA damage response, and immunosurveillance influence hepatocyte division and transformation in the development and progression of HCC. 

Seminar topic: Polyploidy, Replication Stress Driver or Gatekeeper of Chronic Liver Diseases