Bienvenu(e) sur le site de l'Institut Necker Enfants Malades

Exploiter la compréhension de la présentation des antigènes pour l'étude et le traitement du diabète auto-immun

de la science fondamentale :
  • processing des antigènes
  • cellules dendritiques
à la recherche translationnelle :
  • diabète auto-immun
  • diagnostique et thérapeutique
Peter Van Endert
Voies de l’immunité innée et adaptative dans l’autoimmunité et l’autoinflammation
Peter van Endert, M.D. initiated his training in immunology in 1986 at the German Cancer Research Centre, working on anti-idiotype therapy for Non-Hodgkin lymphoma. A post-doctoral stint at Stanford University then introduced him to MHC class I antigen processing. In 1993, he moved to the Necker campus in Paris, continuing to study antigen processing but also interested in cellular responses in type 1 diabetes.
Appointed as INSERM staff scientist in 1998, he became director of INSERM U580 and then INSERM U1013 starting in 2006, and joined INEM as the director of the immunology/infectiology/hematology department in 2014. He was appointed professor of immunology at University Paris Descartes in 2007 and heads the HLA typing laboratory of the Necker hospital. 156 Pub-Med listed publications, h factor 50.

Focus

  • Cell biological and metabolic control of TLR activation and MHC class I cross-presentation
  • Regulation of beta cell-directed autoimmunity by antimicrobial peptides and the intrinsic beta cell reponse

Introduction

Protective anti-pathogen as well as unwanted anti-self immunity implicates sequential activation of innate and adaptive responses. The discovery of intracellular antigen processing machineries starting in the early 90s revealed how ligands recognized in adaptive T cell reponses are produced, although the underlying cell biology, notably concerning (cross-)presentation of exogenous ligands, remains incompletely understood. More recently the focus has shifted to the innate response, preceding and controling the adaptive response. Because activation of the innate response is tightly linked to intracellular receptor trafficking, studying the cell biology of antigen presenting cells is primordial for its understanding. A prime example is the activation of Toll-like receptors (TLRs) in endocytic compartments which in turn modulates cross-presentation, illustrating the intimate connection between innate and adaptive responses. Exciting very recent results including data obtained by us suggest that innate signaling is also affected by the cellular and notably energetic metabolism, which for example by modifying the lipid composition of endocytic membranes controls TLR activation.

While in part specific innate and antigen processing pathways are involved in autoimmune type 1 diabetes (T1D), recent results, including some obtained by our team, indicate a role for beta cell intrinsic mechanisms modulating the course of the autoimmune aggression, as well as for cross-talk between beta cells and the intestinal microbiota. However, the mechanisms underlying both pathways remain largely unexplored.

Research objectives

  • To understand how trafficking in the endocytic pathway regulates TLR activation as well as cross-presentation
  • To elucidate endocytic trafficking pathways underlying efficient cross-presentation by splenic CD169 macrophages and study the contrbution of these cells to generation of T cell immunity
  • To decipher the cell biological alterations, especially in the endolysosomal system, resulting from gene mutations in patients with severe metabolic diseases and to understand how they trigger innate inflammatory pathways
  • To study a novel pathway boosted in the absence of insulin-degrading enzyme (IDE) mediating beta cell regeneration and protection from autoimmunity
  • To study the role of the innate immune system in autoimmune diseases, with a focus on the immunoregulatory potential of anti-microbial peptides and the gut microbiota in type 1 diabetes and in multiple sclerosis

5 main publications

  • Enée E et al.
    ZnT8 is a major CD8+ T cell-recognized autoantigen in pediatric type 1 diabetes.
    Diabetes 61 (2012): 1779-84
  • Miani M, Le Naour J, Waeckel-Énée É, Verma SC, Straube M, van Endert P, Sokol H, Diana J.
    Interplay between the gut microbiota and innate lymphoid cells stimulates ß-defensin 14 expression by pancreatic endocrine cells regulating autoimmune diabetes.
    Cell Metab. (2018) pii: S1550-4131(18)30394-2. doi: 10.1016/j.cmet.2018.06.012
  • Diana J et al.
    Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes.
    Nat. Med. 19 (2013): 65-73
  • Sun J et al.
    Pancreatic beta cells express a cathelicidin-related antimicrobial peptide regulating autoimmune diabetes.
    Immunity 43 (2015): 304-17
  • Van Endert P.
    Intracellular recycling and cross-presentation by MHC class I molecules.
    Immunol. Rev. 272 (2016): 80-96
30 dernières publications

2021

  • Hamel Y, Mauvaus FX, Madrange M, Renard P, Lebreton C, Nemazany I, Pellé O, Goudin N, Tang X, Rodero MP, Tuchmann-Durand C, Nusbaum P, Brindley DN, van Endert P*, de Londay P*. Compromised mitochondrial quality control triggers lipin-1 related rhabdomyolysis. Cell Rep. Med. 2021 Aug 17; 2(8):100370. doi: 10.1016/j.xcrm.2021.100370. (equal contribution)
  • 2020

  • Belabed M, Mauvais F-X, Maschalidi S, Kurowska M, Goudin N, Huang J-D, Fischer A, de Saint Basile G, van Endert P, Sepulveda FE, Ménasché G
    Kinesin-1 is required for antigen cross-presentation by inducing the scission of tubulations from early endosomes in dendritic cells.
    Nat Commun., DOI: 10.1038/s41467-020-15692-0.
  • Evnouchidou I, Chappert P, Benadda S, Zucchetti A, Weimershaus M, Bens M, Caillens V, van Endert P, Guermonprez P, Hivroz C, Gross D, Saveanu L
    Inhibition of endosomal signaling leads to impaired T cell function.
    Nat Commun., in press.
  • Liu P, Zhao L, Loos F, Marty C, Xie W, Martins I, Lachkar S, Qu B, Waeckel-Énée É, Plo I, Vainchenker W, Perez F, Rodriguez D, Lopez-Otin C, van Endert P, Zitvogel L, Kepp, O, Kroemer G
    Immunosuppression by mutated calreticulin released from malignant cells.
    Mol. Cell, 77 (2020): 748-60.
  • 2019

  • Evnochidou I, van Endert P.
    Peptide trimming by endoplasmic reticulum aminopeptidases: role of MHC class I binding and ERAP dimerization.
    Hum. Immunol. 80 (2019): 290-295; doi: 10.1016/j.humimm.2019.01.003
  • Weimershaus M, Evnouchidou I, Li L, van Endert P, Bouvier M. Trimming of MHC Class I Ligands by ERAP Aminopeptidases.
    Methods Mol Biol. (2019):1988:31-43. doi: 10.1007/978-1-4939-9450-2_3
    PMID: 31147930
  • Baracco EE, Stoll G, van Endert P, Zitvogel L, Vacchelli E, Kroemer G.
    Contribution of annexin A1 to anticancer immunosurveillance.
    Oncoimmunology, in press.
  • Montealegre S, Abramova A, de Kanter AF, van Endert P.
    Revisiting the role of MHC class I recycling and Arf6 I cross-presentation by murine dendritic cells.
    Life Science Alliance, in press.
  • Bouchemal N, Ouss L, Brassier A, Barbier V, Gobin S, Hubert L, de Lonlay P, Le Moyec L.
    Diagnosis and phenotypic assessment of trimethylaminuria, and its treatment with riboflavin: H NMR spectroscopy and genetic testing.
    Orphanet J Rare Dis. 2019 Sep 18;14(1):222. doi: 10.1186/s13023-019-1174-6.
    PMID: 31533761
  • Brassier A, Krug P, Lacaille F, Pontoizeau C, Krid S, Sissaoui S, Servais A, Arnoux JB, Legendre C, Charbit M, Scemla A, Francoz C, Benoist JF, Schiff M, Mochel F, Touati G, Broué P, Cano A, Tardieu M, Querciagrossa S, Grévent D, Boyer O, Dupic L, Oualha M, Girard M, Aigrain Y, Debray D, Capito C, Ottolenghi C, Salomon R, Chardot C, de Lonlay P.
    Long-term outcome of methylmalonic aciduria after kidney, liver or combined liverkidney transplantation: the French experience.
    J Inherit Metab Dis. 2019 Sep 16. doi: 10.1002/jimd.12174. [Epub ahead of print]
    PMID: 31525265
  • Efthymiou S, Salpietro V, Malintan N, Poncelet M, Kriouile Y, Fortuna S, De Zorzi R, Payne K, Henderson LB, Cortese A, Maddirevula S, Alhashmi N, Wiethoff S, Ryten M, Botia JA, Provitera V, Schuelke M, Vandrovcova J; SYNAPS Study Group , Walsh L, Torti E, Iodice V, Najafi M, Karimiani EG, Maroofian R, Siquier-Pernet K, Boddaert N, De Lonlay P, Cantagrel V, Aguennouz M, El Khorassani M, Schmidts M, Alkuraya FS, Edvardson S, Nolano M, Devaux J, Houlden H.
    Biallelic mutations in neurofascin cause neurodevelopmental impairment and peripheral demyelination.
    Brain. 2019 Oct 1;142(10):2948-2964. doi: 10.1093/brain/awz248.
    PMID: 31501903
  • Pascreau T, de la Morena-Barrio ME, Lasne D, Serrano M, Bianchini E, Kossorotoff M, Boddaert N, Bruneel A, Seta N, Vicente V, de Lonlay P, Corral J, Borgel D.
    Elevated thrombin generation in patients with congenital disorder of glycosylation and combined coagulation factor deficiencies.
    J Thromb Haemost. 2019 Jul 4. doi: 10.1111/jth.14559. [Epub ahead of print]
    PMID: 31271700
  • Madeo A, Di Rocco M, Brassier A, Bahi-Buisson N, De Lonlay P, Ceballos-Picot I.
    Clinical, biochemical and genetic characteristics of a cohort of 101 French and Italian patients with HPRT deficiency.
    Mol Genet Metab. 2019 Jun;127(2):147-157. doi: 10.1016/j.ymgme.2019.06.001. Epub 2019 Jun 3.
    PMID: 31182398
  • Heard JM, Bellettato C, van Lingen C, Scarpa M; MetabERN collaboration group.
    Research activity and capability in the European reference network MetabERN.
    Orphanet J Rare Dis. 2019 May 29;14(1):119. doi: 10.1186/s13023-019-1091-8.
    PMID: 31142374
  • Molema F, Gleich F, Burgard P, van der Ploeg AT, Summar ML, Chapman KA, Lund AM, Rizopoulos D, Kölker S, Williams M; Additional individual contributors from EIMD.
    Decreased plasma l-arginine levels in organic acidurias (MMA and PA) and decreased plasma branched-chain amino acid levels in urea cycle disorders as a potential cause of growth retardation: Options for treatment.
    Mol Genet Metab. 2019 Apr;126(4):397-405. doi: 10.1016/j.ymgme.2019.02.003. Epub 2019 Feb 25.
    PMID: 30827756
  • Altassan R, Péanne R, Jaeken J, Barone R, Bidet M, Borgel D, Brasil S, Cassiman D, Cechova A, Coman D, Corral J, Correia J, de la Morena-Barrio ME, de Lonlay P, Dos Reis V, Ferreira CR, Fiumara A, Francisco R, Freeze H, Funke S, Gardeitchik T, Gert M, Girad M, Giros M, Grünewald S, Hernández-Caselles T, Honzik T, Hutter M, Krasnewich D, Lam C, Lee J, Lefeber D, Marques-de-Silva D, Martinez AF, Moravej H, Õunap K, Pascoal C, Pascreau T, Patterson M, Quelhas D, Raymond K, Sarkhail P, Schiff M, Seroczyńska M, Serrano M, Seta N, Sykut-Cegielska J, Thiel C, Tort F, Vals MA, Videira P, Witters P, Zeevaert R, Morava E.
    International clinical guidelines for the management of phosphomannomutase 2-congenital disorders of glycosylation: Diagnosis, treatment and follow up.
    J Inherit Metab Dis. 2019 Jan;42(1):5-28. doi: 10.1002/jimd.12024. Review. Erratum in: J Inherit Metab Dis. 2019 May;42(3):577.
    PMID: 30740725
  • Posset R, Garbade SF, Boy N, Burlina AB, Dionisi-Vici C, Dobbelaere D, Garcia-Cazorla A, de Lonlay P, Teles EL, Vara R, Mew NA, Batshaw ML, Baumgartner MR, McCandless SE, Seminara J, Summar M, Hoffmann GF, Kölker S, Burgard P; Additional individual contributors of the UCDC and the E-IMD consortium.
    Transatlantic combined and comparative data analysis of 1095 patients with urea cycle disorders-A successful strategy for clinical research of rare diseases.
    J Inherit Metab Dis. 2019 Jan;42(1):93-106. doi: 10.1002/jimd.12031.
    PMID: 30740724
  • Molema F, Gleich F, Burgard P, van der Ploeg AT, Summar ML, Chapman KA, Barić I, Lund AM, Kölker S, Williams M; Additional individual contributors from E-IMD.
    Evaluation of dietary treatment and amino acid supplementation in organic acidurias and urea-cycle disorders: On the basis of information from a European multicenter registry.
    J Inherit Metab Dis. 2019 Feb 8. doi: 10.1002/jimd.12066. [Epub ahead of print]
    PMID: 30734935
  • Boilève A, Wicker C, Verret B, Leroy F, Malka D, Jozwiak M, Pontoizeau C, Ottolenghi C, De Lonlay P, Ducreux M, Hollebecque A.
    5-Fluorouracil rechallenge after 5-fluorouracil-induced hyperammonemic encephalopathy.
    Anticancer Drugs. 2019 Mar;30(3):313-317. doi: 10.1097/CAD.0000000000000730.
    PMID: 30531368
  • Vuillaumier-Barrot S, Schiff M, Mattioli F, Schaefer E, Dupont A, Dancourt J, Dupré T, Couvineau A, de Baulny HO, de Lonlay P, Seta N, Moore S, Chantret I.
    Wide clinical spectrum in ALG8-CDG: clues from molecular findings suggest an explanation for a milder phenotype in the first-described patient.
    Pediatr Res. 2019 Feb;85(3):384-389. doi: 10.1038/s41390-018-0231-5. Epub 2018 Nov 12.
    PMID: 30420707
  • Rashid T, Nemazanyy I, Paolini C, Tatsuta T, Crespin P, de Villeneuve D, Brodesser S, Benit P, Rustin P, Baraibar MA, Agbulut O, Olivier A, Protasi F, Langer T, Chrast R, de Lonlay P, de Foucauld H, Blaauw B, Pende M.
    Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy.
    EMBO J. 2019 Jan 3;38(1). pii: e99576. doi: 10.15252/embj.201899576. Epub 2018 Nov 12.
    PMID: 30420558
  • 2018

  • Miani M, Le Naour J, Waeckel-Énée É, Verma SC, Straube M, van Endert P, Sokol H, Diana J.
    Interplay between the gut microbiota and innate lymphoid cells stimulates ß-defensin 14 expression by pancreatic endocrine cells regulating autoimmune diabetes.
    Cell Metab. (2018) pii: S1550-4131(18)30394-2. doi: 10.1016/j.cmet.2018.06.012
  • Mari L, Hoefnagel, SJM, Zito D, van de Meent M, van Endert P, Calpe S, Sancho Serra MdC, Heemskerk MHM, Medema JP, van Laarhoven HWM, van Berge Henegouwen MI, Meijer SL, Bergman JJGHM, Milano F, Krishanadath KK.
    MiR-125a-mediated MHC-I expression correlates with an inflamed microenvironment and esophageal adenocarcinoma outcomes.
    Gastroenterology, (2018) 155:784-798.
  • Ducreux S, Dubois V, Amokrane K, Yakoub-Agha I, Labalette M, Michallet M, Rubio MT, Kennel A, Forcade E, Lafarge X, Bulabois CE, Masson D, Daguindau E, Devys A, Moalic V, Quelvennec E, Boudifa A, Picard C, van Endert P, de Matteis M, Delbos F, Filloux M, Pedron B, Renac V, Hau F, Bonneau J, Parissiadis A, Fort M, Dormoy A, Maillard N, Jollet I, Chevallier P, Cesbron A, Bay JO, Quainon F, Garnier F, Socié G, Loiseau P, Porcher R, Peffault de Latour R; Société Francophone de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC) and the Société Francophone d'Histocompatibilité et d'Immunogénétique (SFHI).
    HLA-DRB3/4/5 mismatches are associated with increased risk of acute GvHD in 10/10 martched unrelated donor hematopoietic cell transplantation.
    Am. J. Hematol., doi/ 10.1002/ajh.25133
  • Lawand M, Evnouchidou I, Baranek T, Montealegre S, Tao S, Drexler I, Saveanu L, Si-Tahar M, van Endert P.
    Impact of the TAP-like transporter in cross-presentation and phagosome maturation.
    Mol. Immunol. (2018) pii: S0161-5890(18)30483-8
  • Dubreil C, Sainte Catherine O, Lalatonne Y, Journé C, Ou P, van Endert P, Motte L.
    Tolerogenic iron oxide nanoparticles in type 1 diabetes: biodistribution and pharmacokinetics studies in non-obese diabetic mice.
    Small (2018) Sep 5:e1802053. doi: 10.1002/smll.201802053.
  • Weimershaus M, Mauvais FX, Saveanu L, Adiko C, Babdor J, Abramowa A, Montealegre S, Lawand M, Evnouchidou I, Huber K, Chadt A, Zwick M, Vargas P, Dussiot M, Lennon-Dumenil A, Brocker T, Al-Hasani H, van Endert P.
    Innate immune signals induce anterograde endosome transport promoting cross-presentation.
    Cell Reports (2018) https://doi.org/10.1016/j.celrep.2018.08.041
  • Montealegre S, van Endert P.
    Endocytic recycling of MHC class I molecules in non-professional antigen presenting and dendritic cells.
    Front. Immunol. 9:3098. Doi: 10.3389/fimmu.2018.03098
  • Kauskot A, Pascreau T, Adam F, Bruneel A, Reperant C, Lourenco-Rodrigues MD, Rosa JP, Petermann R, Maurey H, Auditeau C, Lasne D, Denis CV, Bryckaert M, de Lonlay P, Lavenu-Bombled C, Melki J, Borgel D.
    A mutation in the gene coding for the sialic acid transporter SLC35A1 is required for platelet life span but not proplatelet formation.
    Haematologica. 2018 Dec;103(12):e613-e617. doi: 10.3324/haematol.2018.198028. Epub 2018 Aug
    PMID: 30115659
  • Chenouard A, Travert B, Kuster A, de Lonlay P, Bourgoin P.
    Virus or Bacteria: Is It the Only Cause of Sepsis-Induced Rhabdomyolysis?
    Pediatr Crit Care Med. 2018 Jul;19(7):694. doi: 10.1097/PCC.0000000000001550.
    PMID: 29985298
  • Gitiaux C, Kaminska A, Boddaert N, Barcia G, Guéden S, The Tich SN, De Lonlay P, Quijano-Roy S, Hully M, Péréon Y, Desguerre I.
    PLA2G6-associated neurodegeneration: Lessons from neurophysiological findings.
    Eur J Paediatr Neurol. 2018 Sep;22(5):854-861. doi: 10.1016/j.ejpn.2018.05.005. Epub 2018 May 22.
    PMID: 29859652
  • Girard M, Poujois A, Fabre M, Lacaille F, Debray D, Rio M, Fenaille F, Cholet S, Ruel C, Caussé E, Selves J, Bridoux-Henno L, Woimant F, Dupré T, Vuillaumier-Barrot S, Seta N, Alric L, de Lonlay P, Bruneel A.
    CCDC115-CDG: A new rare and misleading inherited cause of liver disease.
    Mol Genet Metab. 2018 Jul;124(3):228-235. doi: 10.1016/j.ymgme.2018.05.002. Epub 2018 May 9.
    PMID: 29759592
  • Gardeitchik T, Mohamed M, Ruzzenente B, Karall D, Guerrero-Castillo S, Dalloyaux D, van den Brand M, van Kraaij S, van Asbeck E, Assouline Z, Rio M, de Lonlay P, Scholl-Buergi S, Wolthuis DFGJ, Hoischen A, Rodenburg RJ, Sperl W, Urban Z, Brandt U, Mayr JA, Wong S, de Brouwer APM, Nijtmans L, Munnich A, Rötig A, Wevers RA, Metodiev MD, Morava E.
    Bi-allelic Mutations in the Mitochondrial Ribosomal Protein MRPS2 Cause Sensorineural Hearing Loss, Hypoglycemia, and Multiple OXPHOS Complex Deficiencies.
    Am J Hum Genet. 2018 Apr 5;102(4):685-695. doi: 10.1016/j.ajhg.2018.02.012. Epub 2018 Mar 22.
    PMID: 29576219
  • de Beaurepaire I, Grévent D, Rio M, Desguerre I, de Lonlay P, Levy R, Dangouloff-Ros V, Bonnefont JP, Barcia G, Funalot B, Besmond C, Metodiev MD, Ruzzenente B, Assouline Z, Munnich A, Rötig A, Boddaert N.
    High predictive value of brain MRI imaging in primary mitochondrial respiratory chain deficiency.
    J Med Genet. 2018 Jun;55(6):378-383. doi: 10.1136/jmedgenet-2017-105094. Epub 2018 Jan 22.
    PMID: 29358270
  • Legendre A, Khraiche D, Ou P, Mauvais FX, Madrange M, Guemann AS, Jais JP, Bonnet D, Hamel Y, de Lonlay P.
    Cardiac function and exercise adaptation in 8 children with LPIN1 mutations.
    Mol Genet Metab. 2018 Mar;123(3):375-381. doi: 10.1016/j.ymgme.2017.12.429. Epub 2018 Jan 5.
    PMID: 29325813
  • 2017

  • Chen K, Chen H, Faas MM, de Haan BJ, Li J, Xiao P, Zhang H, Diana J, de Vos P, Sun J. Specific inulin-type fructan fibers protect against autoimmune diabetes by modulating gut immunity, barrier function and microbiota homeostasis. Mol Nutr Food Res. 2017 Feb 20. doi: 10.1002/mnfr.201601006. [Epub ahead of print]
  • 2016

  • Lawand M, Abramova A, Manceau V, Springer S, van Endert P. TAP-Dependent and -Independent Peptide Import into Dendritic Cell Phagosomes. J Immunol. 2016 Nov 1;197(9):3454-3463.
  • Kokkala P, Mpakali A, Mauvais FX, Papakyriakou A, Daskalaki I, Petropoulou I, Kavvalou S, Papathanasopoulou M, Agrotis S, Fonsou TM, van Endert P, Stratikos E, Georgiadis D. Optimization and Structure-Activity Relationships of Phosphinic Pseudotripeptide Inhibitors of Aminopeptidases That Generate Antigenic Peptides. J Med Chem. 2016 Oct 13;59(19):9107-9123.
  • Chen H, Li L, Weimershaus M, Evnouchidou I, van Endert P, Bouvier M. ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing. Sci Rep. 2016 Aug 12;6:28902. doi: 10.1038/srep28902.
  • Stamogiannos A, Papakyriakou A, Mauvais FX, van Endert P, Stratikos E. Screening Identifies Thimerosal as a Selective Inhibitor of Endoplasmic Reticulum Aminopeptidase 1. ACS Med Chem Lett. 2016 May 31;7(7):681-5.
  • van Endert P. Intracellular recycling and cross-presentation by MHC class I molecules. Immunol Rev. 2016 Jul;272(1):80-96. doi: 10.1111/imr.12424.
  • Hamel Y, Mauvais FX, Pham HP, Kratzer R, Marchi C, Barilleau É, Waeckel-Enée E, Arnoux JB, Hartemann A, Cordier C, Mégret J, Rocha B, de Lonlay P, Beltrand J, Six A, Robert JJ, van Endert P. A unique CD8(+) T lymphocyte signature in pediatric type 1 diabetes. J Autoimmun. 2016 Sep;73:54-63.
  • Lipecka J, Chhuon C, Bourderioux M, Bessard MA, van Endert P, Edelman A, Guerrera IC. Sensitivity of mass spectrometry analysis depends on the shape of the filtration unit used for filter aided sample preparation (FASP). Proteomics. 2016 Jul;16(13):1852-7. doi: 10.1002/pmic.201600103.
  • Antigny F, Hautefort A, Meloche J, Belacel-Ouari M, Manoury B, Rucker-Martin C, Péchoux C, Potus F, Nadeau V, Tremblay E, Ruffenach G, Bourgeois A, Dorfmüller P, Breuils-Bonnet S, Fadel E, Ranchoux B, Jourdon P, Girerd B, Montani D, Provencher S, Bonnet S, Simonneau G, Humbert M, Perros F. Potassium Channel Subfamily K Member 3 (KCNK3) Contributes to the Development of Pulmonary Arterial Hypertension. Circulation. 2016 Apr 5;133(14):1371-85.
  • Mauvais FX, Diana J, van Endert P. Beta cell antigens in type 1 diabetes: triggers in pathogenesis and therapeutic targets. F1000Res. 2016 Apr 22;5. pii: F1000 Faculty Rev-728. doi: 10.12688/f1000research.7411.1.
  • Cluzeau T, Lambert J, Raus N, Dessaux K, Absi L, Delbos F, Devys A, De Matteis M, Dubois V, Filloux M, Fort M, Hau F, Jollet I, Labalette M, Masson D, Mercier B, Pedron B, Perrier P, Picard C, Quainon F, Ramounau-Pigot A, Renac V, Van Endert P, Charron D, Peffault de la Tour R, Taupin JL, Loiseau P. Risk factors and outcome of graft failure after HLA matched and mismatched unrelated donor hematopoietic stem cell transplantation: a study on behalf of SFGM-TC and SFHI. Bone Marrow Transplant. 2016 May;51(5):687-91. doi: 10.1038/bmt.2015.351.
  • Cluzeau T, Lambert J, Raus N, Dessaux K, Absi L, Delbos F, Devys A, De Matteis M, Dubois V, Filloux M, Fort M, Hau F, Jollet I, Labalette M, Masson D, Mercier B, Pedron B, Perrier P, Picard C, Quainon F, Ramounau-Pigot A, Renac V, Van Endert P, Charron D, Peffault de la Tour R, Taupin JL, Loiseau P. Risk factors and outcome of graft failure after HLA matched and mismatched unrelated donor hematopoietic stem cell transplantation: a study on behalf of SFGM-TC and SFHI. Bone Marrow Transplant. 2016 Feb 8. doi: 10.1038/bmt.2015.351.
  • 2015

     
  • Sun J, Furio L, Mecheri R, van der Does AM, Lundeberg E, Saveanu L, Chen Y, van Endert P, Agerberth B, Diana J. Pancreatic β-Cells Limit Autoimmune Diabetes via an Immunoregulatory Antimicrobial Peptide Expressed under the Influence of the Gut Microbiota. Immunity. 2015 Aug 18;43(2):304-17.
  • Costantino F, Talpin A, Evnouchidou I, Kadi A, Leboime A, Said-Nahal R, Bonilla N, Letourneur F, Leturcq T, Ka Z, van Endert P, Garchon HJ, Chiocchia G, Breban M. ERAP1 Gene Expression Is Influenced by Nonsynonymous Polymorphisms Associated With Predisposition to Spondyloarthritis. Arthritis Rheumatol. 2015 Jun;67(6):1525-34.
  • Papakyriakou A, Zervoudi E, Tsoukalidou S, Mauvais FX, Sfyroera G, Mastellos DC, van Endert P, Theodorakis EA, Vourloumis D, Stratikos E. 3,4-diaminobenzoic acid derivatives as inhibitors of the oxytocinase subfamily of M1 aminopeptidases with immune-regulating properties. J Med Chem. 2015 Feb 12;58(3):1524-43.
  • 2014

  • Evnouchidou I, Weimershaus M, Saveanu L, van Endert P. ERAP1-ERAP2 dimerization increases peptide-trimming efficiency. J Immunol. 2014 Jul 15;193(2):901-8.
  • Hsu HT, Janßen L, Lawand M, Kim J, Perez-Arroyo A, Culina S, Gdoura A, Burgevin A, Cumenal D, Fourneau Y, Moser A, Kratzer R, Wong FS, Springer S, van Endert P. Endoplasmic reticulum targeting alters regulation of expression and antigen presentation of proinsulin. J Immunol. 2014 Jun 1;192(11):4957-66.
  • Tenzer S, Crawford H, Pymm P, Gifford R, Sreenu VB, Weimershaus M, de Oliveira T, Burgevin A, Gerstoft J, Akkad N, Lunn D, Fugger L, Bell J, Schild H, van Endert P, Iversen AK. HIV-1 adaptation to antigen processing results in population-level immune evasion and affects subtype diversification. Cell Rep. 2014 Apr 24;7(2):448-63.
  • Culina S, Mauvais FX, Hsu HT, Burgevin A, Guénette S, Moser A, van Endert P. No major role for insulin-degrading enzyme in antigen presentation by MHC molecules. PLoS One. 2014 Feb 7;9(2):e88365. doi: 10.1371/journal.pone.0088365. eCollection 2014. PubMed PMID: 24516642; PubMed Central PMCID: PMC3917890.
  • Diana J, Lehuen A. Macrophages and β-cells are responsible for CXCR2-mediated neutrophil infiltration of the pancreas during autoimmune diabetes. EMBO Mol Med. 2014 Jun 26;6(8):1090-104.
  • 2013

  • Beuzelin C, Evnouchidou I, Rigolet P, Cauvet-Burgevin A, Girard PM, Dardalhon D, Culina S, Gdoura A, van Endert P, Francesconi S. Deletion of the fission yeast homologue of human insulinase reveals a TORC1-dependent pathway mediating resistance to proteotoxic stress. PLoS One. 2013 Jun 24;8(6):e67705. doi: 10.1371/journal.pone.0067705. Print 2013. PubMed PMID: 23826334; PubMed Central PMCID: PMC3691139.
  • Ma Y, Adjemian S, Mattarollo SR, Yamazaki T, Aymeric L, Yang H, Portela Catani JP, Hannani D, Duret H, Steegh K, Martins I, Schlemmer F, Michaud M, Kepp O, Sukkurwala AQ, Menger L, Vacchelli E, Droin N, Galluzzi L, Krzysiek R, Gordon S, Taylor PR, Van Endert P, Solary E, Smyth MJ, Zitvogel L, Kroemer G. Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells. Immunity. 2013 Apr 18;38(4):729-41.
  • Saveanu L, Babdor J, Lawand M, van Endert P. Insulin-regulated aminopeptidase and its compartment in dendritic cells. Mol Immunol. 2013 Sep;55(2):153-5.
  • Chercheur statutaire
    Barbara Bertocci
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    Pascale De Lonlay
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    Julien Diana
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    Parrain(s)
    S.A.R. la Princesse Caroline de Hanovre qui, à travers la Fondation Princesse Grace, soutient déjà la recherche medicale et tout ce qui contribue à soulager les enfants malades en France et dans le monde, a accepté de s'engager à nos cotés pour que ce centre de medecine moleculaire, tourné entre autres vers les pathologies des enfants, prenne de vitesse les maladies et continue à relever les defis actuels.

    INEM - Organigramme