Institut Necker Enfants Malades

Sagi Shapira joined INEM in January 2022 as Team Leader Systems Biology Laboratory

Sagi earned a Master of Public Health degree in Infectious Disease Epidemiology at Yale. D. at UPenn in Immunology and Parasitology in the lab of Chris Hunter, followed by a postdoc at Harvard/Broad Institute in the lab of Nir Hacohen where he developed a research program aimed at capturing the full range of host and viral factors that modulate influenza infection. Since joining Columbia as an assistant professor, Sagi's lab has focused on identifying biological principles at the interface of virology and innate immunity. His lab is truly multidisciplinary, merging tools and concepts from several disciplines to do what he calls "hypothesis-driven systems biology" - implementing both experimental and computational methods - an approach that has allowed him to make non-incremental advances in the study of pathogen-host relationships.

Sagi joined Columbia University as an assistant professor in the Department of Systems Biology in 2011. Since then, the Shapira lab has focused on uncovering the molecular grammar that governs pathogen-host interactions and illuminating the fundamental principles of biology - always in the broader context of public health.

Sagi Shapira says "We use experimental, analytical and computational tools and methods to quantitatively and qualitatively identify the functional determinants of human infectious diseases. I will highlight some of the biological questions that have motivated our work, summarise the contributions we have made to the study of virus-host biology, and explain how this knowledge can guide discovery and help decipher the genetic and molecular circuits at the interface of pathogen-host interactions and human physiology. "

Five major original publications

Lasso G, Honig B, Shapira S.D. A sweep of earth's virome reveals host-guided viral mimicry and points to determinants of human disease. Cell Systems 2020. Jan 20;12(1):82-91.e3. doi: 10.1016/j.cels.2020.09.006. Epub 2020 Oct 13.

Ramlall V, Thangaraj P.M, Cem Meydan C, Foox J, Butler D, Kim J, May B, De Freitas J.K, Glicksberg B.S, Mason C.E, Tatonetti N.P, Shapira S.D. Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection. Nature Medicine 2020 Oct;26(10):1609-1615. doi: 10.1038/s41591-020-1021-2

Lasso G, Mayer S.V, Winkelmann E.R, Chu T, Elliot O, Patino-Galindo J.A , Park K, Rabadan R, Honig B, Shapira S.D. A Structure informed atlas of human-virus interactions. Cell 2019. Sep 5;178(6):1526-1541.e16. doi: 10.1016/j.cell.2019.08.005

Abe T, Lee A, Sitharam R, Kesner J, Rabadan R, Shapira SD. Germ-Cell-Specific Inflammasome Component NLRP14 Negatively Regulates Cytosolic Nucleic Acid Sensing to Promote Fertilization. Immunity 2017 Apr 18;46(4):621-634. doi: 10.1016/j.immuni.2017.03.020

Shapira S.D, Gat-Viks I, Shum B.O.V, Dricot A, de Grace M.M, Wu L, Gupta P.B, Hao T, Silver S.J, Root D.E, Hill D.E, Regev A, Hacohen N. A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection. Cell 2009. Dec 24;139(7):1255-67. doi: 10.1016/j.cell.2009.12.018

Permanent researcher