Five major original publications
Bonucci M., Kuperwasser N., Barbe S., Koka V., de Villeneuve D., Zhang C., Srivastava N., Jia X., Stokes M.P., Bienaimé F., Verkarre V., Lopez J.B., Jaulin F., Pontoglio M., Terzi F., Delaval B., Piel M., Pende M. (2020). mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division. Nat Commun. Jun 24;11(1):3200. doi: 10.1038/s41467-020-16978-z.
Rashid T., Nemazanyy I., Paolini C., Tatsuta T., Crespin P., de Villeneuve D., Brodesser S., Benit P., Rustin P., Baraibar M.A., Agbulut O., Olivier A., Protasi F., Langer T., Chrast R., de Lonlay P., de Foucauld H., Blaauw B., Pende M. (2018). Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy. EMBO J. Jan 3;38(1):e99576. doi: 10.15252/embj.201899576. Epub 2018 Nov 12.
Barilari M., Bonfils G., Treins C., Koka V., De Villeneuve D., Fagrega S., Pende M. (2017). ZRF1 is a novel S6 kinase substrate that drives the senescence programme. EMBO J. Mar 15;36(6):736-750. doi: 10.15252/embj.201694966. Epub 2017 Feb.
Liang N., Zhang C., Dill P., Panasyuk G., Pion D., Koka V., Gallazzini M., Olson E.N., Lam H., Henske E.P., Dong Z., Apte U., Pallet N., Johnson R.L., Terzi F., Kwiatkowski D.J., Scoazec J-Y., Martignoni G., Pende M. (2014). Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex. J Exp Med. 211, 2249-2263. doi: 10.1084/jem.20140341. Epub 2014 Oct 6.
Aguilar V., Alliouachene S., Sotiropoulos A., Sobering A., Athea Y., Djouadi F., Miraux S., Thiaudière E., Foretz M., Viollet B., Diolez P., Bastin J., Benit P., Rustin P., Carling D., Sandri M., Ventura-Clapier R., Pende M. (2007). S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase. Cell Metabolism. Jun;5(6):476-87. doi: 10.1016/j.cmet.2007.05.006.
List of publications
2021
de la Calle Arregui C., Plata-Gomez A.B., Deleyto-Seldas N., Garcia F., Ortega-Molina A., Abril-Garrido J., Rodriguez E., Nemazanyy I., Tribouillard L., de Martino A., Caleiras E., Campos-Olivas R., Mulero F., Laplante M., Muñoz J., Pende M., Sabio G., Sabatini D.M., Efeyan A. (2021). Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling. Nat. Comm, 12(1):3660. doi: 10.1038/s41467-021-23857-8.
2020
Bonucci M., Kuperwasser N., Barbe S., Koka V., de Villeneuve D., Zhang C., Srivastava N., Jia X., Stokes M.P., Bienaimé F., Verkarre V., Lopez J.B., Jaulin F., Pontoglio M., Terzi F., Delaval B., Piel M., Pende M. (2020). S6K1-dependent polycystic kidney in Tuberous Sclerosis disconnects the controls of cell division rate and orientation by mTOR. Nat. Comm, 11(1):3200. doi: 10.1038/s41467-020-16978-z.
2019
Murakami S., Nemazanyy I., White S.M., Chen H., Nguyen C.D.K., Graham G.T., Saur D., Pende M., Yi C. (2019). A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas. Dev Cell, doi: 10.1016/j.devcel.2019.07.022.
White S.M., Avantaggiati M.L., Nemazanyy I., Di Poto C., Yang Y., Pende M., Gibney G.T., Ressom H.W., Field J., Atkins M.B., Yi C. (2019). YAP/TAZ Inhibition Induces Metabolic and Signaling Rewiring Resulting in Targetable Vulnerabilities in NF2-Deficient Tumor Cells. Dev Cell, 49, 425-443.
Iershov A., Nemazanyy I., Alkhoury C., Girard M., Barth E., Cagnard N., Montagner A., Chretien D., Rugarli E.I., Guillou H., Pende M., Panasyuk G. (2019). The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα. Nat Comm., 10, 1566.
Thery M., Pende M. (2019). Golgi mechanics controls lipid metabolism. Nat. Cell. Biol.
2018
Rashid T., Nemazanyy I., Paolini C., Tatsuta T., Crespin P., de Villeneuve D., Brodesser S., Benit P., Rustin P., Baraibar M.A., Agbulut O., Olivier A., Protasi F., Langer T., Chrast R., de Lonlay P., de Foucauld H., Blaauw B., Pende M. (2018). Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy. EMBO J, 38.
2017
Patitucci C., Couchy G., Bagattin A., Cañeque T., de Reyniès A., Scoazec J-Y, Rodriguez R., Pontoglio M., Zucman-Rossi J., Pende M.* and Panasyuk G. (2017) *corresponding author. HNF1α suppresses steatosis associated liver cancer by inhibiting PPARγ transcription. Journal of Clinical Investigation, 127, 1873-1888, doi: 10.1172/JCI90327.
Barilari M., Bonfils G., Treins C., Koka V., De Villeneuve D., Fagrega S., Pende M. (2017) ZRF1 is a novel S6 kinase substrate that drives the senescence program. EMBO J., 36, 736-750. doi: 10.15252/embj.201694966.
Panasyuk G, Patitucci C, Espeillac C, Pende M. The role of the mTOR pathway during liver regeneration and tumorigenesis. Ann Endocrinol (Paris). 2013;74(2):121-2. PMID: 23566619
Patitucci C, Couchy G, Bagattin A, Cañeque T, de Reyniès A, Scoazec JY, Rodriguez R, Pontoglio M, Zucman-Rossi J, Pende M, Panasyuk G. Hepatocyte nuclear factor 1α suppresses steatosis-associated liver cancer by inhibiting PPARγ transcription. J Clin Invest. 2017;127(5):1873-1888. PMID: 28394260
Barilari M, Bonfils G, Treins C, Koka V, De Villeneuve D, Fabrega S, Pende M. ZRF1 is a novel S6 kinase substrate that drives the senescence programme. EMBO J. 2017 Feb 27. pii: e201694966. doi: 10.15252/embj.201694966. [Epub ahead of print]
2016
Marabita M, Baraldo M, Solagna F, Ceelen JJ, Sartori R, Nolte H, Nemazanyy I, Pyronnet S, Kruger M, Pende M, Blaauw B. S6K1 Is Required for Increasing Skeletal Muscle Force during Hypertrophy. Cell Rep. 2016 Oct 4;17(2):501-513.
Sahin M, Henske EP, Manning BD, Ess KC, Bissler JJ, Klann E, Kwiatkowski DJ, Roberds SL, Silva AJ, Hillaire-Clarke CS, Young LR, Zervas M, Mamounas LA; Tuberous Sclerosis Complex Working Group to Update the Research Plan. Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference. Pediatr Neurol. 2016 Jul;60:1-12.
Houssaini A, Abid S, Derumeaux G, Wan F, Parpaleix A, Rideau D, Marcos E, Kebe K, Czibik G, Sawaki D, Treins C, Dubois-Randé JL, Li Z, Amsellem V, Lipskaia L, Pende M, Adnot S. Selective TSC1 Deletion in Smooth Muscle Activates mTOR Signaling and Induces Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2016 Sep;55(3):352-67.
Marsan E, Ishida S, Schramm A, Weckhuysen S, Muraca G, Lecas S, Liang N, Treins C, Pende M, Roussel D, Le Van Quyen M, Mashimo T, Kaneko T, Yamamoto T, Sakuma T, Mahon S, Miles R, Leguern E, Charpier S, Baulac S. Depdc5 knockout rat: A novel model of mTORopathy. Neurobiol Dis. 2016 May;89:180-9.
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, and al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222. No abstract available.
2015
Liang N, Pende M. YAP enters the mTOR pathway to promote tuberous sclerosis complex. Mol Cell Oncol. 2015 May 1;2(4):e998100. doi: 10.1080/23723556.2014.998100. eCollection 2015 Oct-Dec.
Nemazanyy I, Montagnac G, Russell RC, Morzyglod L, Burnol AF, Guan KL, Pende M, Panasyuk G. Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. Nat Commun. 2015 Sep 21;6:8283. doi: 10.1038/ncomms9283.
Faller WJ, Jackson TJ, Knight JR, Ridgway RA, Jamieson T, Karim SA, Jones C, Radulescu S, Huels DJ, Myant KB, Dudek KM, Casey HA, Scopelliti A, Cordero JB, Vidal M, Pende M, Ryazanov AG, Sonenberg N, Meyuhas O, Hall MN, Bushell M, Willis, AE, Sansom OJ. mTORC1-mediated translational elongation limits intestinal tumour initiation and growth. Nature. 2015 Jan 22;517(7535):497-500.
2014
Liang N, Zhang C, Dill P, Panasyuk G, Pion D, Koka V, Gallazzini M, Olson EN, Lam H, Henske EP, Dong Z, Apte U, Pallet N, Johnson RL, Terzi F, Kwiatkowski DJ, Scoazec JY, Martignoni G, Pende M. Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex. J Exp Med. 2014 Oct 20;211(11):2249-63.
Chauvin C, Koka V, Nouschi A, Mieulet V, Hoareau-Aveilla C, Dreazen A, Cagnard N, Carpentier W, Kiss T, Meyuhas O, Pende M. Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program. Oncogene. 2014 Jan 23;33(4):474-83.
2013
Canaud G, Bienaimé F, Viau A, Treins C, Baron W, Nguyen C, Burtin M, Berissi S, Giannakakis K, Muda AO, Zschiedrich S, Huber TB, Friedlander G, Legendre C, Pontoglio M, Pende M, Terzi F. AKT2 is essential to maintain podocyte viability and function during chronic kidney disease. Nat Med. 2013 Oct;19(10):1288-96.
Michot C, Mamoune A, Vamecq J, Viou MT, Hsieh LS, Testet E, Lainé J, Hubert L, Dessein AF, Fontaine M, Ottolenghi C, Fouillen L, Nadra K, Blanc E, Bastin J, Candon S, Pende M, Munnich A, Smahi A, Djouadi F, Carman GM, Romero N, de Keyzer Y, de Lonlay P. Combination of lipid metabolism alterations and their sensitivity to inflammatory cytokines in human lipin-1-deficient myoblasts. Biochim Biophys Acta. 2013 Dec;1832(12):2103-14.
Nemazanyy I, Espeillac C, Pende M, Panasyuk G. Role of PI3K, mTOR and Akt2signalling in hepatic tumorigenesis via the control of PKM2 expression. Biochem Soc Trans. 2013 Aug;41(4):917-22.
Nemazanyy I, Blaauw B, Paolini C, Caillaud C, Protasi F, Mueller A, Proikas-Cezanne T, Russell RC, Guan KL, Nishino I, Sandri M, Pende M, Panasyuk G. Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease. EMBO Mol Med. 2013 Jun;5(6):870-90.
Panasyuk G, Patitucci C, Espeillac C, Pende M. The role of the mTOR pathway during liver regeneration and tumorigenesis. Ann Endocrinol (Paris). 2013 May;74(2):121-2.
2012
Nadra K, Médard JJ, Mul JD, Han GS, Grès S, Pende M, Metzger D, Chambon P, Cuppen E, Saulnier-Blache JS, Carman GM, Desvergne B, Chrast R. Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue. Mol Cell Biol. 2012 Dec;32(23):4794-810.
Treins C, Alliouachene S, Hassouna R, Xie Y, Birnbaum MJ, Pende M. The combined deletion of S6K1 and Akt2 deteriorates glycemic control in a high-fat diet. Mol Cell Biol. 2012 Oct;32(19):4001-11.
Panasyuk G, Espeillac C, Chauvin C, Pradelli LA, Horie Y, Suzuki A, Annicotte JS, Fajas L, Foretz M, Verdeguer F, Pontoglio M, Ferré P, Scoazec JY, Birnbaum MJ, Ricci JE, Pende M. PPARγ contributes to PKM2 and HK2 expression in fatty liver. Nat Commun. 2012 Feb 14;3:672.
Kalista S, Schakman O, Gilson H, Lause P, Demeulder B, Bertrand L, Pende M, Thissen JP. The type 1 insulin-like growth factor receptor (IGF-IR) pathway is mandatory for the follistatin-induced skeletal muscle hypertrophy. Endocrinology. 2012 Jan;153(1):241-53.