Welcome on the Necker-Enfants Malades Institute website

Studying cellular and molecular mechanisms underlying dysregulated immune responses

from basic science:
  • allergy
  • immune tolerance
to the translational research:
  • asthma
  • autoimmune diabetes
Lucienne Chatenoud
Maria Leite-De-Moraes
Immunoregulation and Immunopathology

Lucienne CHATENOUD is Professor in Immunology at Paris Descartes University, Head of the Immunology Laboratory at Hôpital Necker-Enfants Malades and Senior Professor at the Institut Universitaire de France. Her research focused on pathogenic and regulatory immune mechanisms in transplantation and autoimmunity and on the devise of strategies to induce/restore immune tolerance. Lucienne Chatenoud pioneered the use of CD3 monoclonal antibodies to treat autoimmune diabetes, a strategy presently in clinical development.

Maria LEITE DE MORAES is Research Director (DR1) at CNRS. She made seminal discoveries on the ontogeny and function of invariant Natural Killer T (iNKT) and on their role in experimental and clinical allergic asthma. She described iNKT17 cells as a distinct lineage. Her current focus is the role of Innate Like T cells, namely iNKT, γδ T and MAIT cells, in allergy and autoimmunity.

Focus

We are primarily interested with dissecting cellular and molecular mechanisms of immunoregulation and immunopathology and how these can be harnessed, using novel biotherapies or biotherapy strategies, to develop treatments transferable to the clinic in autoimmunity, allergy, organ or cell transplantation.

Introduction

Over the last years we took advantage of the complementary expertise of the lead investigators in autoimmunity and allergy to dissect cellular and molecular mechanisms of immunoregulation and immunopathology and how these can be harnessed, using novel biotherapies or biotherapy strategies, tools and know-how to develop treatments transferable to the clinic in autoimmunity, allergy, organ or cell transplantation.

The strength of the team is that, besides conventional and genetic engineering modified mice, we also used an experimental model we have been working on for the last 25 years, the non-obese diabetic (NOD) mouse, which spontaneously develops a genetically driven autoimmune syndrome including insulin-dependent diabetes and Sjogren's syndrome.

Salient contributions include:

  1. Original description of a novel subset of invariant NKT (iNKT) cells, the IL-17-producing iNKT17 lymphocytes. They are implicated in inflammatory responses including allergic asthma and autoimmune type I diabetes. iNKT17 cells acquire their functional properties in the thymus where SAP-dependent signals are essential for the fate decisions driving their differentiation into iNKT1 (major IFNγ-producers), iNKT2 (IL-4 producers) or NKT17 cells.
  2. Initial description of the pivotal role of iNKT cells in experimental allergic asthma. The later was translated to the clinic showing the increase of iNKT cells in the brochoalveolar lavage of pediatric patients presenting severe asthma. Major efforts are presently devoted to dissect the implication of distinct innate like T lymphocytes namely, iNKT but also γδ T and MAIT (Mucosal-Associated Invariant T) cells in the physiopathology of experimental and clinical asthma.
  3. Demonstration that a single Toll Like Receptor agonist recapitulates the in vivo protection on both autoimmunity and allergy afforded by infectious agents and bacterial extracts. A new opening to a plausible explanation for the "Hygiene hypothesis" and to novel therapeutic perspectives for the prevention of these pathologies that represent a major health problem in western countries. This field of activity has been granted an European Research Council (ERC) funding (PI: J-F Bach).
  4. First clinical proof of concept of an immunointervention strategy pioneered by our team (use of CD3 monoclonal antibodies) that is successful at promoting operational immune tolerance (long-term control of pathogenic responses in absence of chronic immunosuppression) in the context of an established autoimmune disease (autoimmune type 1 diabetes) : demonstration through a long-term follow-up of patients included in a phase II randomized placebo-controlled trial, recently confirmed by a pharmaceutically-driven phase III trial.
  5. Demonstration that the tolerance-promoting ability of CD3 monoclonal antibodies can be extended from autoimmunity to organ transplantation as shown in islet, skin and cardiac transplantation. Potential use of the strategy in regenerative medicine to promote long-term survival of cardiac cell progenitors derived from embryonic stem cells.

Research objectives

Using state of the art technology, we want to re-evaluate the important problem of the penetrance of autoimmune and allergic diseases through the study of new genetic factors, of epigenetic marks and/or the influence of newly well-characterized immune regulatory mechanisms.

Last 30 publications

2018

  • Bach JF. The hygiene hypothesis in autoimmunity: the role of pathogens and commensals. Nat Rev Immunol. 2018;18(2):105-20. doi: 10.1038/nri.2017.111. PubMed PMID: 29034905.
  • Belkadi A, Dietrich C, Machavoine F, Victor JR, Leite-de-Moraes M. gammadelta T cells amplify Blomia tropicalis-induced allergic airway disease. Allergy. 2018. doi: 10.1111/all.13618. PubMed PMID: 30291622.
  • Besancon A, Goncalves T, Valette F, Mary C, Vanhove B, Chatenoud L, You S. A selective CD28 antagonist and rapamycin synergise to protect against spontaneous autoimmune diabetes in NOD mice. Diabetologia. 2018;61(8):1811-6. doi: 10.1007/s00125-018-4638-7. PubMed PMID: 29845333.
  • Besancon A, Goncalves T, Valette F, Dahllof MS, Mandrup-Poulsen T, Chatenoud L, You S. Oral histone deacetylase inhibitor synergises with T cell targeted immunotherapy to preserve beta cell metabolic function and induce stable remission of new-onset autoimmune diabetes in NOD mice. Diabetologia. 2018;61(2):389-98. doi: 10.1007/s00125-017-4459-0. PubMed PMID: 29030662.
  • Briand C, Fremond ML, Bessis D, Carbasse A, Rice GI, Bondet V, Duffy D, Chatenoud L, Blanche S, Crow YJ, Neven B. Efficacy of JAK1/2 inhibition in the treatment of chilblain lupus due to TREX1 deficiency. Ann Rheum Dis. 2018. doi: 10.1136/annrheumdis-2018-214037. PubMed PMID: 30282666.
  • Ghiasi SM, Dahllof MS, Osmai Y, Osmai M, Jakobsen KK, Aivazidis A, Tyrberg B, Perruzza L, Prause MCB, Christensen DP, Fog-Tonnesen M, Lundh M, Grassi F, Chatenoud L, Mandrup-Poulsen T. Regulation of the beta-cell inflammasome and contribution to stress-induced cellular dysfunction and apoptosis. Mol Cell Endocrinol. 2018. doi: 10.1016/j.mce.2018.08.001. PubMed PMID: 30121202.
  • Landon-Cardinal O, Friedman D, Guiguet M, Laforet P, Heming N, Salort-Campana E, Jouen F, Allenbach Y, Boyer O, Chatenoud L, Eymard B, Sharshar T, Benveniste O. Efficacy of Rituximab in Refractory Generalized anti-AChR Myasthenia Gravis. J Neuromuscul Dis. 2018;5(2):241-9. doi: 10.3233/JND-180300. PubMed PMID: 29865089.
  • Lezmi G, Leite-de-Moraes M. Invariant Natural Killer T and Mucosal-Associated Invariant T Cells in Asthmatic Patients. Front Immunol. 2018;9:1766. doi: 10.3389/fimmu.2018.01766. PubMed PMID: 30105031; PubMed Central PMCID: PMCPMC6077286.
  • Lezmi G, Abou Taam R, Dietrich C, Chatenoud L, de Blic J, Leite-de-Moraes M. Circulating IL-17-producing mucosal-associated invariant T cells (MAIT) are associated with symptoms in children with asthma. Clin Immunol. 2018;188:7-11. doi: 10.1016/j.clim.2017.11.009. PubMed PMID: 29196148.
  • Orabona C, Mondanelli G, Pallotta MT, Carvalho A, Albini E, Fallarino F, Vacca C, Volpi C, Belladonna ML, Berioli MG, Ceccarini G, Esposito SM, Scattoni R, Verrotti A, Ferretti A, De Giorgi G, Toni S, Cappa M, Matteoli MC, Bianchi R, Matino D, Iacono A, Puccetti M, Cunha C, Bicciato S, Antognelli C, Talesa VN, Chatenoud L, Fuchs D, Pilotte L, Van den Eynde B, Lemos MC, Romani L, Puccetti P, Grohmann U. Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1in juvenile diabetes. JCI Insight. 2018;3(6). doi: 10.1172/jci.insight.96244. PubMed PMID: 29563329; PubMed Central PMCID: PMCPMC5926942.
  • Rignault-Bricard R, Machavoine F, Mecheri S, Hermine O, Schneider E, Dy M*, Leite-de-Moraes M*. IL-3-producing basophils are required to exacerbate airway hyper-responsiveness in a murine inflammatory model. Allergy. 2018. doi: 10.1111/all.13480. PubMed PMID: 29777594. *corresponding authors.
  • You S, Chatenoud L. Revisiting the phenotypic and genetic profiling of anergic T cells mediating long-term transplant tolerance. Curr Opin Organ Transplant. 2018;23(1):83-9. doi: 10.1097/MOT.0000000000000494. PubMed PMID: 29194071
  • 2017

  • Besancon A, Michaud B, Beltrand J, Goncalves T, Jais JP, Polak M, Chatenoud L, Robert JJ. Revisiting autoimmune gastritis in children and adolescents with type 1 diabetes. Pediatr Diabetes. 2017;18(8):772-6. doi: 10.1111/pedi.12482. PubMed PMID: 28004477.
  • Besancon A, Baas M, Goncalves T, Valette F, Waldmann H, Chatenoud L, You S. The Induction and Maintenance of Transplant Tolerance Engages Both Regulatory and Anergic CD4(+) T cells. Front Immunol. 2017;8:218. doi: 10.3389/fimmu.2017.00218. PubMed PMID: 28321218; PubMed Central PMCID: PMCPMC5337867.
  • Belo R, Santarem N, Pereira C, Perez-Cabezas B, Macedo F, Leite-de-Moraes M*, Cordeiro-da-Silva A*. Leishmania infantum Exoproducts Inhibit Human Invariant NKT Cell Expansion and Activation. Front Immunol. 2017;8:710. doi: 10.3389/fimmu.2017.00710. PubMed PMID: 28674535; PubMed Central PMCID: PMCPMC5474685. *corresponding authors.
  • Bodemer C, Guillet G, Cambazard F, Boralevi F, Ballarini S, Milliet C, Bertuccio P, La Vecchia C, Bach JF, de Prost Y. Adjuvant treatment with the bacterial lysate (OM-85) improves management of atopic dermatitis: A randomized study. PLoS One. 2017;12(3):e0161555. doi: 10.1371/journal.pone.0161555. PubMed PMID: 28333952; PubMed Central PMCID: PMCPMC5363804.
  • Mondanelli G, Albini E, Pallotta MT, Volpi C, Chatenoud L, Kuhn C, Fallarino F, Matino D, Belladonna ML, Bianchi R, Vacca C, Bicciato S, Boon L, Ricci G, Grohmann U, Puccetti P, Orabona C. The Proteasome Inhibitor Bortezomib Controls Indoleamine 2,3-Dioxygenase 1 Breakdown and Restores Immune Regulation in Autoimmune Diabetes. Front Immunol. 2017;8:428. doi: 10.3389/fimmu.2017.00428. PubMed PMID: 28450863; PubMed Central PMCID: PMCPMC5390013.
  • Smith N, Pietrancosta N, Davidson S, Dutrieux J, Chauveau L, Cutolo P, Dy M, Scott-Algara D, Manoury B, Zirafi O, McCort-Tranchepain I, Durroux T, Bachelerie F, Schwartz O, Munch J, Wack A, Nisole S, Herbeuval JP. Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement. Nat Commun. 2017;8:14253. doi: 10.1038/ncomms14253. PubMed PMID: 28181493; PubMed Central PMCID: PMCPMC5309800.
  • 2016

  • Besançon A, Michaud B, Beltrand J, Goncalves T, Jais JP, Polak M, Chatenoud L, Robert JJ. Revisiting autoimmune gastritis in children and adolescents with type 1 diabetes. Pediatr Diabetes. 2016 Dec 22. doi: 10.1111/pedi.12482. [Epub ahead of print]
  • Amat F, Tallon P, Foray AP, Michaud B, Lambert N, Saint-Pierre P, Chatenoud L, Just J. Control of asthma by omalizumab: the role of CD4+ Foxp3+ regulatory T cells. Clin Exp Allergy. 2016 Dec;46(12):1614-1616.
  • Gottenberg JE, Brocq O, Perdriger A, Lassoued S, Berthelot JM, Wendling D, Euller-Ziegler L, Soubrier M, Richez C, Fautrel B, Constantin AL, Mariette X, Morel J, Gilson M, Cormier G, Salmon JH, Rist S, Lioté F, Marotte H, Bonnet C, Marcelli C, Sellam J, Meyer O, Solau-Gervais E, Guis S, Ziza JM, Zarnitsky C, Chary-Valckenaere I, Vittecoq O, Saraux A, Pers YM, Gayraud M, Bolla G, Claudepierre P, Ardizzone M, Dernis E, Breban MA, Fain O, Balblanc JC, Aberkane O, Vazel M, Back C, Candon S, Chatenoud L, Perrodeau E, Sibilia J, Ravaud P. Non-TNF-Targeted Biologic vs a Second Anti-TNF Drug to Treat Rheumatoid Arthritis in Patients With Insufficient Response to a First Anti-TNF Drug: A Randomized Clinical Trial. JAMA. 2016 Sep 20;316(11):1172-1180.
  • Chatenoud L. Precision medicine for autoimmune disease. Nat Biotechnol. 2016 Sep 8;34(9):930-2.
  • Ziyab AH, Mukherjee N, Ewart S, Arshad SH, Karmaus W, Turati F, Bertuccio P, Galeone C, Pelucchi C, Naldi L, Bach JF, Vecchia CL, Chatenoud L. Filaggrin gene loss-of-function variants modify the effect of breast-feeding on eczema risk in early childhood. Allergy. 2016 Sep;71(9):1371-3.
  • Michel ML, Lenoir C, Massot B, Diem S, Pasquier B, Sawa S, Rignault-Bricard R, Lehuen A, Eberl G, Veillette A, Leite-de-Moraes M, Latour S. SLAM-associated protein favors the development of iNKT2 over iNKT17 cells. Eur J Immunol. 2016 Sep;46(9):2162-74.
  • Larousserie F, Bsiri L, Dumaine V, Dietrich C, Audebourg A, Radenen-Bussière B, Anract P, Vacher-Lavenu MC, Devergne O. Frontline Science: Human bone cells as a source of IL-27 under inflammatory conditions: role of TLRs and cytokines. J Leukoc Biol. 2016 Sep 27. pii: jlb.3HI0616-280R. [Epub ahead of print]
  • Trinquand A, Dos Santos NR, Tran Quang C, Rocchetti F, Zaniboni B, Belhocine M, Da Costa de Jesus C, Lhermitte L, Tesio M, Dussiot M, Cosset FL, Verhoeyen E, Pflumio F, Ifrah N, Dombret H, Spicuglia S, Chatenoud L, Gross DA, Hermine O, Macintyre E, Ghysdael J, Asnafi V. Triggering the TCR Developmental Checkpoint Activates a Therapeutically Targetable Tumor Suppressive Pathway in T-cell Leukemia. Cancer Discov. 2016 Jun 28. [Epub ahead of print] PMID: 27354269.
  • Kuhn C, Besançon A, Lemoine S, You S, Marquet C, Candon S, Chatenoud L. Regulatory mechanisms of immune tolerance in type 1 diabetes and their failures. J Autoimmun. 2016 Jul;71:69-77.
  • Turati F, Bertuccio P, Galeone C, Pelucchi C, Naldi L, Bach JF, La Vecchia C, Chatenoud L; HYGIENE Study Group. Early weaning is beneficial to prevent atopic dermatitis occurrence in young children. Allergy. 2016 Jun;71(6):878-88.
  • Perdigoto AL, Chatenoud L, Bluestone JA, Herold KC. Inducing and Administering Tregs to Treat Human Disease. Front Immunol. 2016 Jan 22;6:654. doi: 10.3389/fimmu.2015.00654. eCollection 2015. Review.
  • You S, Chatenoud L. Autoimmune Diabetes: An Overview of Experimental Models and Novel Therapeutics. Methods Mol Biol. 2016;1371:117-42.
  • Luque Y, Jamme M, Rabant M, DeWolf S, Noël LH, Thervet E, Chatenoud L, Snanoudj R, Anglicheau D, Legendre C, Candon S, Zuber J. Long-term CD4 lymphopenia is associated with accelerated decline of kidney allograft function. Nephrol Dial Transplant. 2016 Mar;31(3):487-95.
  • Calderon D, Prot M, You S, Marquet C, Bellamy V, Bruneval P, Valette F, de Almeida P, Wu JC, Pucéat M, Menasché P, Chatenoud L. Control of Immune Response to Allogeneic Embryonic Stem Cells by CD3 Antibody-Mediated Operational Tolerance Induction. Am J Transplant. 2016 Feb;16(2):454-67.
  • Gouadon E, Moore-Morris T, Smit NW, Chatenoud L, Coronel R, Harding SE, Jourdon P, Lambert V, Rucker-Martin C, Pucéat M. Concise Review: Pluripotent Stem Cell-Derived Cardiac Cells, A Promising Cell Source for Therapy of Heart Failure: Where Do We Stand? Stem Cells. 2016 Jan;34(1):34-43. doi: 10.1002/stem.2205. Epub 2015 Sep 16.
  • Baas M, Besançon A, Goncalves T, Valette F, Yagita H, Sawitzki B, Volk HD, Waeckel-Enée E, Rocha B, Chatenoud L, You S. TGFβ-dependent expression of PD-1 and PD-L1 controls CD8(+) T cell anergy in transplant tolerance. Elife. 2016 Jan 29;5:e08133. doi: 10.7554/eLife.08133.
  • 2015

  • Elhage R, Cheraï M, Levacher B, Darrasse-Jeze G, Baillou C, Zhao X, Khatib AM, Piaggio E, Klatzmann D. C-terminal cleavage of human Foxp3 at a proprotein convertase motif abrogates its suppressive function. Scand J Immunol. 2015 Apr;81(4):229-39.
  • Chatenoud L. Biotherapies targeting T and B cells: from immune suppression to immune tolerance. Curr Opin Pharmacol. 2015 Aug;23:92-7.
  • Candon S, Perez-Arroyo A, Marquet C, Valette F, Foray AP, Pelletier B, Milani C, Ventura M, Bach JF, Chatenoud L. Antibiotics in early life alter the gut microbiome and increase disease incidence in a spontaneous mouse model of autoimmune insulin-dependent diabetes. PLoS One. 2015 May 13;10(5):e0125448. doi:10.1371/journal.pone.0125448. eCollection 2015. PubMed PMID: 25970503; PubMedCentral PMCID: PMC4430542.
  • Snanoudj R, Claas FH, Heidt S, Legendre C, Chatenoud L, Candon S. Restricted specificity of peripheral alloreactive memory B cells in HLA-sensitized patients awaiting a kidney transplant. Kidney Int. 2015 Jun;87(6):1230-40.
  • Botta C, Darini C, Darrasse-Jèze G, Podsypanina K. Methods to study primary tumor cells and residual tumor cells in mouse models of oncogene dependence. Methods Mol Biol. 2015;1267:381-94.
  • You S. Differential sensitivity of regulatory and effector T cells to cell death: a prerequisite for transplant tolerance. Front Immunol. 2015 May 19;6:242.
  • Soares RV, Do TM, Mabondzo A, Pons G, Chhun S. Ontogeny of ABC and SLC transporters in the microvessels of developing rat brain. Fundam Clin Pharmacol. 2015 Dec 13. doi: 10.1111/fcp.12175. [Epub ahead of print]
  • Chatenoud L. World Diabetes Day: Perspectives on immunotherapy of Type 1 Diabetes. Eur J Immunol. 2015 Nov;45(11):2968-70.
  • Ounissi M, Benkirane A, Dempsey E, Soares R, Jullien V, Pons G, Chhun S. A review of potential pharmacogenetic effects on catecholamine responses. Drug Metab Rev. 2015 Nov;47(4):558-64.
  • 2014

  • Besancon A, Michaud B, Beltrand J, Goncalves T, Jais JP, Polak M, Chatenoud L, Robert JJ. Revisiting autoimmune gastritis in children and adolescents with type 1 diabetes. Pediatr Diabetes. 2017;18(8):772-6. doi: 10.1111/pedi.12482. PubMed PMID: 28004477.
  • Besancon A, Baas M, Goncalves T, Valette F, Waldmann H, Chatenoud L, You S. The Induction and Maintenance of Transplant Tolerance Engages Both Regulatory and Anergic CD4(+) T cells. Front Immunol. 2017;8:218. doi: 10.3389/fimmu.2017.00218. PubMed PMID: 28321218; PubMed Central PMCID: PMCPMC5337867.
  • Belo R, Santarem N, Pereira C, Perez-Cabezas B, Macedo F, Leite-de-Moraes M*, Cordeiro-da-Silva A*. Leishmania infantum Exoproducts Inhibit Human Invariant NKT Cell Expansion and Activation. Front Immunol. 2017;8:710. doi: 10.3389/fimmu.2017.00710. PubMed PMID: 28674535; PubMed Central PMCID: PMCPMC5474685. *corresponding authors.
  • Bodemer C, Guillet G, Cambazard F, Boralevi F, Ballarini S, Milliet C, Bertuccio P, La Vecchia C, Bach JF, de Prost Y. Adjuvant treatment with the bacterial lysate (OM-85) improves management of atopic dermatitis: A randomized study. PLoS One. 2017;12(3):e0161555. doi: 10.1371/journal.pone.0161555. PubMed PMID: 28333952; PubMed Central PMCID: PMCPMC5363804.
  • Mondanelli G, Albini E, Pallotta MT, Volpi C, Chatenoud L, Kuhn C, Fallarino F, Matino D, Belladonna ML, Bianchi R, Vacca C, Bicciato S, Boon L, Ricci G, Grohmann U, Puccetti P, Orabona C. The Proteasome Inhibitor Bortezomib Controls Indoleamine 2,3-Dioxygenase 1 Breakdown and Restores Immune Regulation in Autoimmune Diabetes. Front Immunol. 2017;8:428. doi: 10.3389/fimmu.2017.00428. PubMed PMID: 28450863; PubMed Central PMCID: PMCPMC5390013.
  • Smith N, Pietrancosta N, Davidson S, Dutrieux J, Chauveau L, Cutolo P, Dy M, Scott-Algara D, Manoury B, Zirafi O, McCort-Tranchepain I, Durroux T, Bachelerie F, Schwartz O, Munch J, Wack A, Nisole S, Herbeuval JP. Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement. Nat Commun. 2017;8:14253. doi: 10.1038/ncomms14253. PubMed PMID: 28181493; PubMed Central PMCID: PMCPMC5309800.
  • Besançon A, Michaud B, Beltrand J, Goncalves T, Jais JP, Polak M, Chatenoud L, Robert JJ. Revisiting autoimmune gastritis in children and adolescents with type 1 diabetes. Pediatr Diabetes. 2016 Dec 22. doi: 10.1111/pedi.12482. [Epub ahead of print]
  • Amat F, Tallon P, Foray AP, Michaud B, Lambert N, Saint-Pierre P, Chatenoud L, Just J. Control of asthma by omalizumab: the role of CD4+ Foxp3+ regulatory T cells. Clin Exp Allergy. 2016 Dec;46(12):1614-1616.
  • Gottenberg JE, Brocq O, Perdriger A, Lassoued S, Berthelot JM, Wendling D, Euller-Ziegler L, Soubrier M, Richez C, Fautrel B, Constantin AL, Mariette X, Morel J, Gilson M, Cormier G, Salmon JH, Rist S, Lioté F, Marotte H, Bonnet C, Marcelli C, Sellam J, Meyer O, Solau-Gervais E, Guis S, Ziza JM, Zarnitsky C, Chary-Valckenaere I, Vittecoq O, Saraux A, Pers YM, Gayraud M, Bolla G, Claudepierre P, Ardizzone M, Dernis E, Breban MA, Fain O, Balblanc JC, Aberkane O, Vazel M, Back C, Candon S, Chatenoud L, Perrodeau E, Sibilia J, Ravaud P. Non-TNF-Targeted Biologic vs a Second Anti-TNF Drug to Treat Rheumatoid Arthritis in Patients With Insufficient Response to a First Anti-TNF Drug: A Randomized Clinical Trial. JAMA. 2016 Sep 20;316(11):1172-1180.
  • Chatenoud L. Precision medicine for autoimmune disease. Nat Biotechnol. 2016 Sep 8;34(9):930-2.
  • Ziyab AH, Mukherjee N, Ewart S, Arshad SH, Karmaus W, Turati F, Bertuccio P, Galeone C, Pelucchi C, Naldi L, Bach JF, Vecchia CL, Chatenoud L. Filaggrin gene loss-of-function variants modify the effect of breast-feeding on eczema risk in early childhood. Allergy. 2016 Sep;71(9):1371-3.
  • Michel ML, Lenoir C, Massot B, Diem S, Pasquier B, Sawa S, Rignault-Bricard R, Lehuen A, Eberl G, Veillette A, Leite-de-Moraes M, Latour S. SLAM-associated protein favors the development of iNKT2 over iNKT17 cells. Eur J Immunol. 2016 Sep;46(9):2162-74.
  • Larousserie F, Bsiri L, Dumaine V, Dietrich C, Audebourg A, Radenen-Bussière B, Anract P, Vacher-Lavenu MC, Devergne O. Frontline Science: Human bone cells as a source of IL-27 under inflammatory conditions: role of TLRs and cytokines. J Leukoc Biol. 2016 Sep 27. pii: jlb.3HI0616-280R. [Epub ahead of print]
  • Trinquand A, Dos Santos NR, Tran Quang C, Rocchetti F, Zaniboni B, Belhocine M, Da Costa de Jesus C, Lhermitte L, Tesio M, Dussiot M, Cosset FL, Verhoeyen E, Pflumio F, Ifrah N, Dombret H, Spicuglia S, Chatenoud L, Gross DA, Hermine O, Macintyre E, Ghysdael J, Asnafi V. Triggering the TCR Developmental Checkpoint Activates a Therapeutically Targetable Tumor Suppressive Pathway in T-cell Leukemia. Cancer Discov. 2016 Jun 28. [Epub ahead of print] PMID: 27354269.
  • Kuhn C, Besançon A, Lemoine S, You S, Marquet C, Candon S, Chatenoud L. Regulatory mechanisms of immune tolerance in type 1 diabetes and their failures. J Autoimmun. 2016 Jul;71:69-77.
  • Turati F, Bertuccio P, Galeone C, Pelucchi C, Naldi L, Bach JF, La Vecchia C, Chatenoud L; HYGIENE Study Group. Early weaning is beneficial to prevent atopic dermatitis occurrence in young children. Allergy. 2016 Jun;71(6):878-88.
  • Perdigoto AL, Chatenoud L, Bluestone JA, Herold KC. Inducing and Administering Tregs to Treat Human Disease. Front Immunol. 2016 Jan 22;6:654. doi: 10.3389/fimmu.2015.00654. eCollection 2015. Review.
  • You S, Chatenoud L. Autoimmune Diabetes: An Overview of Experimental Models and Novel Therapeutics. Methods Mol Biol. 2016;1371:117-42.
  • Luque Y, Jamme M, Rabant M, DeWolf S, Noël LH, Thervet E, Chatenoud L, Snanoudj R, Anglicheau D, Legendre C, Candon S, Zuber J. Long-term CD4 lymphopenia is associated with accelerated decline of kidney allograft function. Nephrol Dial Transplant. 2016 Mar;31(3):487-95.
  • Calderon D, Prot M, You S, Marquet C, Bellamy V, Bruneval P, Valette F, de Almeida P, Wu JC, Pucéat M, Menasché P, Chatenoud L. Control of Immune Response to Allogeneic Embryonic Stem Cells by CD3 Antibody-Mediated Operational Tolerance Induction. Am J Transplant. 2016 Feb;16(2):454-67.
  • Gouadon E, Moore-Morris T, Smit NW, Chatenoud L, Coronel R, Harding SE, Jourdon P, Lambert V, Rucker-Martin C, Pucéat M. Concise Review: Pluripotent Stem Cell-Derived Cardiac Cells, A Promising Cell Source for Therapy of Heart Failure: Where Do We Stand? Stem Cells. 2016 Jan;34(1):34-43. doi: 10.1002/stem.2205. Epub 2015 Sep 16.
  • Baas M, Besançon A, Goncalves T, Valette F, Yagita H, Sawitzki B, Volk HD, Waeckel-Enée E, Rocha B, Chatenoud L, You S. TGFβ-dependent expression of PD-1 and PD-L1 controls CD8(+) T cell anergy in transplant tolerance. Elife. 2016 Jan 29;5:e08133. doi: 10.7554/eLife.08133.
  • Elhage R, Cheraï M, Levacher B, Darrasse-Jeze G, Baillou C, Zhao X, Khatib AM, Piaggio E, Klatzmann D. C-terminal cleavage of human Foxp3 at a proprotein convertase motif abrogates its suppressive function. Scand J Immunol. 2015 Apr;81(4):229-39.
  • Chatenoud L. Biotherapies targeting T and B cells: from immune suppression to immune tolerance. Curr Opin Pharmacol. 2015 Aug;23:92-7.
  • Candon S, Perez-Arroyo A, Marquet C, Valette F, Foray AP, Pelletier B, Milani C, Ventura M, Bach JF, Chatenoud L. Antibiotics in early life alter the gut microbiome and increase disease incidence in a spontaneous mouse model of autoimmune insulin-dependent diabetes. PLoS One. 2015 May 13;10(5):e0125448. doi:10.1371/journal.pone.0125448. eCollection 2015. PubMed PMID: 25970503; PubMedCentral PMCID: PMC4430542.
  • Snanoudj R, Claas FH, Heidt S, Legendre C, Chatenoud L, Candon S. Restricted specificity of peripheral alloreactive memory B cells in HLA-sensitized patients awaiting a kidney transplant. Kidney Int. 2015 Jun;87(6):1230-40.
  • Botta C, Darini C, Darrasse-Jèze G, Podsypanina K. Methods to study primary tumor cells and residual tumor cells in mouse models of oncogene dependence. Methods Mol Biol. 2015;1267:381-94.
  • You S. Differential sensitivity of regulatory and effector T cells to cell death: a prerequisite for transplant tolerance. Front Immunol. 2015 May 19;6:242.
  • Soares RV, Do TM, Mabondzo A, Pons G, Chhun S. Ontogeny of ABC and SLC transporters in the microvessels of developing rat brain. Fundam Clin Pharmacol. 2015 Dec 13. doi: 10.1111/fcp.12175. [Epub ahead of print]
  • Chatenoud L. World Diabetes Day: Perspectives on immunotherapy of Type 1 Diabetes. Eur J Immunol. 2015 Nov;45(11):2968-70.
  • Ounissi M, Benkirane A, Dempsey E, Soares R, Jullien V, Pons G, Chhun S. A review of potential pharmacogenetic effects on catecholamine responses. Drug Metab Rev. 2015 Nov;47(4):558-64.
  • Baas MC, Kuhn C, Valette F, Mangez C, Duarte MS, Hill M, Besançon A, Chatenoud L, Cuturi MC, You S. Combining autologous dendritic cell therapy with CD3 antibodies promotes regulatory T cells and permanent islet allograft acceptance. J Immunol. 2014 Nov 1;193(9):4696-703.
  • Chatenoud L. Immunology. Teaching the immune system "self" respect and tolerance. Science. 2014 Jun 20;344(6190):1343-4.
  • Michaud B, Aroulandom J, Baiz N, Amat F, Gouvis-Echraghi R, Candon S, Foray AP, Couderc R, Bach JF, Chatenoud L, Just J. Casein-specific IL-4- and IL-13-secreting T cells: a tool to implement diagnosis of cow's milk allergy. Allergy. 2014 Nov;69(11):1473-80.
  • Snanoudj R, Candon S, Roelen DL, Jais JP, Claas FH, Legendre C, Chatenoud L. Peripheral B-cell phenotype and BAFF levels are associated with HLA immunization in patients awaiting kidney transplantation. Transplantation. 2014 May 15;97(9):917-24.
  • Permanent researcher
    Jean-François Bach
    Researcher
    +33 (0)1 44 41 43 83
    Christine Bodemer
    Professor Researcher
    Lucienne Chatenoud
    Professor Researcher
    +33 (0)1 44 49 53 83
    Stéphanie Chhun
    -
    +33 (0)1 44 49 53 43
    Jacques De Blic
    Professor Researcher
    +33(0)1 44 49 48 38
    Michel Dy
    Researcher
    +33 (0)1 44 49 53 93
    Céline Greco
    -
    Smail Hadjrabia
    Professor Researcher
    Maria Leite-De-Moraes
    Researcher
    +33 (0)1 44 49 53 94
    Guillaume Lezmi
    Professor Researcher
    +33(0)1 44 49 48 38
    Non permanent researcher
    Baptiste Moreira
    -
    Coralie Pecquet
    Researcher
    +33(0)1 44 49 53 69
    Permanent engineer
    Céline Dietrich
    Technician
    +33 (0)1 44 49 40 00
    François Machavoine
    Engineer
    +33 (0)1 44 49 59 55
    Cindy Marquet
    Engineer
    +33 (0)1 44 49 53 69
    Fabrice Valette
    Assistant in Experimental and Instrumental Biology
    +33 (0)1 44 49 53 69
    PhD
    Anne-Perrine Foray
    PhD Student
    +33 (0)1 44 49 53 69
    Address

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    Support(s)
    HRH Princess Caroline of Hanover, who through the Princess Grace Foundation, already supports medical research and anything that helps to relieve the sick children in France and around the world, has agreed to commit to our side so that our Center of Molecular medicine continues to meet the current challenges and fight diseases, and in particular the ones affecting children.

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