Welcome on the Necker-Enfants Malades Institute website
The Necker-Enfants Malades Institute is administered by one Director assisted by the two department Heads and one General secretary in charge the administration. Each PI or CoPI is responsible for his (her) scientific project and for the use of his (her) allocated space
Fabiola Terzi
INEM Director
Mario Pende
Marco Pontoglio
Director of "Growth and Signalling" Dept
Peter Van Endert
Simon Fillatreau
Director of "Immunology, Infectiology and Haematology" (I2H) Dept
Sophie Koutouzov
General Secretary
Research Teams
Seventeen research teams are founding members of the Necker-Enfants Malades Institute. The teams are grouped in two departments: a department of cell biology (Growth and Signalling) and a department of, Immunology, Infectiology and Haematology (I2H). The Necker-Enfants Malades Institute currently comprises 103 senior scientists, one third of whom are medical doctors, 60 technicians and engineers, 35 postdoctoral fellows and 37 PhD students.
«Cell biology (Growth and Signalling)» Department
Vincent Goffin
Prolactin and Growth Hormone Pathophysiology: Translational Approaches
Franck Oury
Hormonal regulation of brain development and functions
Mario Pende
Cell growth control by nutrients
Etienne Morel
Autophagy pathway and intracellular compartments dynamics
Marco Pontoglio
Epigenetics and development
Isabelle Sermet Gaudelus
Cystic fibrosis and other epithelial respiratory protein misfolding diseases
Fabiola Terzi
Mecanisms and therapeutic strategies of chronic kidney disease
Guillaume Canaud
Precision medicine for diseases of the mTOR pathway
Ganna Panasyuk
Mechanisms of Nutrient Sensing
«Immunology, infectiology and Haematology (I2H)» Department
Laurence Arbibe
Genome plasticity and infections
Elizabeth Macintyre & Vahid Asnafi
Normal and pathological lymphoid differentiation
Lucienne Chatenoud & Maria Leite-De-Moraes
Immunoregulation and Immunopathology
Claude-Agnès Reynaud & Jean-Claude Weill
Development of the immune system
Xavier Nassif & Alain Charbit
Pathogenesis of systemic infections
Peter Van Endert
Innate and adaptive immune pathways in autoimmunity and autoinflammation
Sophie Ezine & Flora Zavala
Lymphopoiesis and immunoregulatory hematopoietic progenitors
Simon Fillatreau
Immunity in health and disease
Pamela Schnupf
Host-Microbiota Interaction
Benedicte Manoury
Immune Response and Danger Signals
ERC grantees
Current ERC grantees
  • Guillaume CANAUD : ERC Papastudy - Podocyte Adaptation Proliferation and Ageing
  • Simon FILLATREAU : ERC - PREG-LAB - Distinctive characterization of regulatory plasma cells and pro-inflammatory B cells in immunity: their origins, molecular properties, and cellular fates
  • Ganna PANASYUK : ERC MetaboSENS - Metabolic integration by nutrient SENSing
  • Claude-Agnès REYNAUD : ERC B-RESPONSE : Memory and innate-like B-cell subsets: deciphering a multi-layered B-cell response in mice and humans
  • Pamela SCHNUPF : ERC NICHEADAPT - Deciphering the niche adaptations of a gut commensal involved in educating the host immune system
Former ERC grantees
  • Jean-François  BACH : ERC HYGIENE - The hygiene hypothesis: revisiting the concept by integrating epidemiology and mechanistic studies
  • Mario PENDE : ERC RariTOR - mTOR pathophysiology in rare human diseases
  • Jean-Claude WEILL : ERC Advanced - MEMO-B : The B cell memory program: cell fate determinants and functional diversity of B cell subsets
Scientific Advisory Board
The Scientific Advisory Board (SAB) is composed of 7 international scientific personalities, experts in their field. Its role will be to advise the INEM on scientific orientations and the recruitment of new groups. If necessary, the SAB might be consulted for strategic decisions. The chairman of the scientific advisory board is Jules Hoffmann, Nobel Prize in Medicine 2011.
Pr. Ana Maria Cuervo
Albert Einstein College of Medicine, Department of Developmental and Molecular Biology, New York (USA)
Pr. Jules Hoffmann
University of Strasbourg, Institute for Molecular and Cellular Biology, Strasbourg (France)
Pr. Luca Scorrano
University of Padua, Department of Biology, Padua (Italy) Venetian Institute of Molecular Medicine, Padua (Italy)
Pr. Eric Gerd Pamer
Memorial Sloan-Kettering Cancer Center, Department of Medicine, Infectious Diseases Service, New York (USA)
Pr. Dr. Gunter Hammerling
German Cancer Research Center (DKFZ), Heidelberg (Germany)
Pr. Markus Muschen
University of California San Francisco, Department of Laboratory Medicine, San Francisco (USA)
Pr. Dr. Gerd Walz
University of Freiburg, BIOSS Center for Biological Signalling Studies, Freiburg (Germany)
General Services

The administrative platform is led by the General Secretary with the assistance of the administrative and financial management. Its mission is the management of human resources, finance and movable heritage. It also coordinates the general kitchen and washroom services, prevention & safety, technology transfer and development, informatics.

Sophie Koutouzov
General Secretary
Josiane Sage-Preat
Administrative and financial Director

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HRH Princess Caroline of Hanover, who through the Princess Grace Foundation, already supports medical research and anything that helps to relieve the sick children in France and around the world, has agreed to commit to our side so that our Center of Molecular medicine continues to meet the current challenges and fight diseases, and in particular the ones affecting children.

INEM - Organigramme