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Tuesday 5 of December, 2023
Just Published: The AMPK-Sirtuin 1-YAP axis is regulated by fluid flow intensity and controls autophagy flux in kidney epithelial cells by Aurore Claude-Taupin
In their recently published paper in Nature Communications, Aurore Claude-Taupin et al. explore the critical role of shear stress, a known regulator of renal function, and its dysregulation in various kidney diseases.

Building on prior research highlighting the significance of primary cilium-dependent autophagy in kidney epithelial cells' response to fluid flow, a new dimension has emerged.

Key Insights
  • Nuclear YAP/TAZ's involvement in negatively regulating autophagy flux in response to fluid flow in kidney epithelial cells.
  • This crosstalk is facilitated by primary cilium-dependent activation of AMPK and SIRT1, independently of the Hippo pathway.
  • Validation of the YAP/TAZ-autophagy molecular dialog in in vivo models including a zebrafish model of kidney development and a mouse model of unilateral ureteral obstruction.
  • In vitro assay replicating accelerated flow in early chronic kidney disease (CKD) stages activates YAP, leading to a primary cilium-dependent inhibition of autophagic flux.
  • Confirmation of the YAP/autophagy relationship in renal biopsies from patients with diabetic kidney disease (DKD), the primary cause of CKD.
The findings shed light on the pivotal roles of YAP/TAZ and autophagy in translating fluid flow into cellular and physiological responses, providing valuable insights into the molecular mechanisms of kidney diseases.

Read the full article here: https://lnkd.in/g673vuZh

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HRH Princess Caroline of Hanover, who through the Princess Grace Foundation, already supports medical research and anything that helps to relieve the sick children in France and around the world, has agreed to commit to our side so that our Center of Molecular medicine continues to meet the current challenges and fight diseases, and in particular the ones affecting children.

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