Mitochondrial dysfunction is a critical process involved in plethora of pathologies. Morgan Gallazzini’s group in the team of Fabiola Terzi identified Lipocalin-2 as an inducer of mitochondrial dysfunction. By combining in cells and in vivo renal disease models the team demonstrated that Lipocalin-2 regulates mTOR activity and thus induces mitochondrial fragmentation and loss of function.

This work has been published in Cell Reports and is available to read at the following link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(23)01043-4