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Monday 24 of April, 2023
Identification of AKT-FoxO1 as an on/off gate for marginal zone B cell development

The team of Simon Fillatreau identified in a collaborative work with the team of Dr. Nadine Hövelmeyer (Mainz University, Germany) the chief role of the AKT-FoxO1 signaling axis in the formation of mouse and human marginal zone B cells, which are involved in host defense against encapsulated bacteria (Cell Reports, doi: 10.1016/j.celrep.2023.112378). Remarkably, AKT signaling also conferred B cells with increased innate function, a distinctive functional property of marginal zone B cells, thus linking the signals controlling the development of these cells to their function. Furthermore, they identified CD148 as a receptor present at higher level on the surface of marginal zone B cells in mice and humans, compared to other B cell subsets, and whose expression in B cells is controlled by AKT signaling intensity, potentially providing a key to evaluate AKT signaling and track innate B cells.


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HRH Princess Caroline of Hanover, who through the Princess Grace Foundation, already supports medical research and anything that helps to relieve the sick children in France and around the world, has agreed to commit to our side so that our Center of Molecular medicine continues to meet the current challenges and fight diseases, and in particular the ones affecting children.

INEM - Organigramme