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Tuesday 2nd of February, 2021
Time-dependent maturation of memory B cells against SARS-Cov-2 with improved recognition of the virus receptor binding site

Immune memory is the mechanism that protects us against re-infection by pathogens. The success of vaccines is based on this defense strategy that consists in the production of blood antibodies and of memory B cells, able to reactivate into antibody-secreting cells upon a new infection. The team led by M. Mahévas, J.-C. Weill and C.-A. Reynaud has followed memory B cells in two cohorts of patients with mild or severe SARS-Cov-2 infection over 6 months, in collaboration with the team of F. Rey at Pasteur Institute. They show that memory B cells persist and even improve their recognition of the spike protein virus-binding domain over time, as well as their production of neutralizing antibodies. These encouraging results suggest moreover that the broad recognition potential of memory B cells and their capacity for selective proliferation may allow them to adapt to some virus variants and generate a still effective response upon a drifted virus challenge (Sokal, Chappert et al., Cell, February, 2021).

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HRH Princess Caroline of Hanover, who through the Princess Grace Foundation, already supports medical research and anything that helps to relieve the sick children in France and around the world, has agreed to commit to our side so that our Center of Molecular medicine continues to meet the current challenges and fight diseases, and in particular the ones affecting children.

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