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Welcome on the Necker-Enfants Malades Institute website
Friday 30 of October, 2020
Cell Reports _ Developmental Renal Glomerular Defects at the Origin of Glomerulocystic Disease

The research group led by Marco Pontoglio at the “Institut Necker Enfants Malades” has discovered a novel genetically programmed morphogenetic process that plays an important role in renal glomerulogenesis. The dysfunction of this process leads to self-strangled glomeruli that generate cysts upon glomerular filtration. This process tackles a so far unappreciated developmental issue: the separation of the urinary and vascular poles in early nephron precursors. This study is published in Cell Reports 2020 Oct 27;33(4):108304. DOI:https://doi.org/10.1016/j.celrep.2020.108304

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HRH Princess Caroline of Hanover, who through the Princess Grace Foundation, already supports medical research and anything that helps to relieve the sick children in France and around the world, has agreed to commit to our side so that our Center of Molecular medicine continues to meet the current challenges and fight diseases, and in particular the ones affecting children.

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