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Lundi 9 mars 2020
The Schnupf lab discovers a missing link in the life-cycle of the immunostimulatory gut commensal SFB

The gut commensal Segmented Filamentous Bacterium (SFB) is found in a wide range of vertebrates where it undergoes an unusual life-cycle. Unicellular bacteria called intracellular offsprings (IOs) attach to the ileal epithelium, grow out into filaments and then divide and differentiate to produce new IOs that are released from the filament end. In a publication in January 2020 in the journal Nature Microbiology, the Lab or Host-Microbiota Interaction directed by, Pamela Schnupf discovered that half of the tear-drop shaped IOs released from their mother filament are flagellated. Flagella are appendages that permit bacterial movement and, together with the ability to sense chemoattractants, enable the bacterium to reach its replicative niche. The team also showed that the major structural component of this appendage can be sensed by the host’s innate immune system. These findings add a missing link of immunological importance to the life-cycle of SFB, a potentially medically-relevant commensal.

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S.A.R. la Princesse Caroline de Hanovre qui, à travers la Fondation Princesse Grace, soutient déjà la recherche medicale et tout ce qui contribue à soulager les enfants malades en France et dans le monde, a accepté de s'engager à nos cotés pour que ce centre de medecine moleculaire, tourné entre autres vers les pathologies des enfants, prenne de vitesse les maladies et continue à relever les defis actuels.

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