About the host laboratory
The Goffin Lab (PRL/GH Pathophysiology - Translational Approaches) has >25-year international visibility in onco-endocrinology and develops research projects related to the resistance to treatment of hormone-dependent tumors (breast, prostate). The group currently involves 16 people including tenure basic scientists, clinicians and technicians, post-docs, graduate & undergraduate students.
About the project
Fully-funded project supported by the French National Agency of Research (ANR), built on solid data involving luminal progenitor-like LSCmed cells discovered by our group in a mouse model of benign prostatic hyperplasia (BPH). LSCmed cells combine androgen-independence, stem/progenitor properties, cell plasticity and therapeutic resistance (Baurès et al, Nature Reviews Urology 2022). The candidate will use various preclinical models of BPH including Pb-PRL mice, mouse- and patient-derived organoids, cell lines, and human tissue biocollections to elucidate LSCmed cell dialog with microenvironment and challenge innovative targeting strategies. The project involves established collaborative networks of biologists, immunologists, urologists, pathologists and bioinformaticians.
Your profile
We are seeking a highly motivated and creative candidate (m/f) with a strong drive for independent research. The ideal candidate will have expertise in animal, cell, and molecular biology, encompassing techniques such as histology, IHC/IF, cell sorting, cell culture, organoids, qPCR, immunoblots, and more. All applicants are expected to benefit from excellent written and oral communication skills. Proficiency in bioinformatics and/or spatial biology would be a valuable addition.
The selected candidate will be offered a one-year contract renewable up to 2.5 years.
How to apply
Please submit your application including a concise statement of research interest and CV as soon as possible but not later than December 15th, 2023 for a start date Q1 of 2024. Applications will be considered upon submission.
Application contact: Vincent Goffin (Team leader): vincent.goffin@inserm.fr
Curious or have questions? Don't hesitate to reach out to us for an informal chat.
Additional information
Keywords: Benign prostate hyperplasia, immune-epithelial dialog, stem/progenitor properties, therapeutic targeting, scRNA-seq, spatial biology, organoids, mouse/human models
About the host laboratory
The Goffin Lab has >25-year international visibility in onco-endocrinology and develops research projects related to the resistance to treatment of hormone-dependent tumors (breast, prostate). The group currently involves 16 people including tenure basic scientists, clinicians and technicians, post-docs, graduate & undergraduate students.
About the project
Fully-funded project supported by the French National Institute of Cancer (INCa), built on solid data involving luminal progenitor-like LSCmed cells (first isolated by our group) that combine castration-tolerance, stem/progenitor properties, cell plasticity and tumor-initiating capacities (Baurès et al, Nature Reviews Urology 2022). The candidate will use preclinical models of prostate cancer/CRPC including transgenic mice, mouse- and patient-tumor-derived organoids, cell lines, and patient biocollections to elucidate LSCmed cell plasticity underlying treatment escape, and challenge innovative targeting strategies. This project involves established collaborative networks of biologists, urologists, pathologists and bioinformaticians.
Your profile
We are seeking a highly motivated and creative candidate (m/f) with a strong drive for independent research. The ideal candidate will have expertise in animal, cell, and molecular biology, encompassing techniques such as histology, IHC/IF, cell sorting, cell culture, organoids, qPCR, immunoblots, and more. All applicants are expected to benefit from excellent written and oral communication skills. Proficiency in bioinformatics and/or spatial biology would be a valuable addition.
The selected candidate will be offered a one-year contract renewable one.
How to apply
Please submit your application including a concise statement of research interest and CV as soon as possible but not later than December 15th, 2023, for a start date Q1 of 2024. Applications will be considered upon submission.
Application contact: Vincent Goffin (Team leader): vincent.goffin@inserm.fr
Curious or have questions? Don't hesitate to reach out to us for an informal chat.
Additional information
Keywords: Prostate cancer, castration-resistance, stem/progenitor cells, cell plasticity, therapeutic targeting, scRNA-seq, spatial biology, organoids, mouse/human models.
The "Cystic fibrosis and other epithelial respiratory protein misfolding diseases" lab is excited to announce an opportunity for a dedicated and motivated postdoctoral fellow to join our research team, located at INEM - Institut Necker Enfants Malades in Paris.
Our research aims to understand the inflammation pathways remodeled by highly efficient CFTR modulation including the protease anti-protease balance, oxidative stress and interaction with innate immune cells. This will be based on a multi-omic approach of patient primary airway cultures under different experimental conditions and study of sputum samples collected longitudinally in a pediatric cohort.
The ideal candidate will have expertise in standard molecular biology techniques and mammalian cell culture; experience in inflammation is desirable but not essential.
Highly motivated candidates with a PhD or MD, PhD are welcome to apply. Applicants should possess strong laboratory, analytical, interpersonal and communication skills.
INEM is located in the Necker Hospital campus which provides an exceptional scientific and academic environment. Administered jointly by INSERM, CNRS and the Université de Paris, INEM benefits from close contacts with clinicians and state-of-the-art technological platforms in one of France’s foremost research centered universities.
The successful candidate will be offered a 24-to-36-month contract with salary depending on experience. This position is available immediately, though start date is flexible.
Interested candidates should email a brief cover letter indicating their research interests, experience and career goals, CV, and contact information for reference to isabelle.sermet@aphp.fr