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Group leader positions at Institut Necker Enfants Malades, Université Paris Cité, Paris-France
Thursday 11 of May, 2023
The Institut Necker Enfants Malades (INEM, https://www.institut-necker-enfants-malades.fr/) invites applications for two group leader positions. Excellent future prospects and an upwards-scientific track record will be the principal selection criteria. We promote equal opportunities, strongly encouraging applications from female candidates and welcome applications from early career scientists as well as established PIs who wish to join INEM.
Candidates should have an innovative research program complementing the existing strengths in one of the main areas in relation to INEM departments:
1) control of tissue growth, metabolism, organelle homeostasis and interorgan communication at the molecular, cell biology or patho-physiology level. In this context, bringing an expertise in primary cell organoids or organ-on-chip technology might be considered an asset;
2) fundamental and translational studies in immunology, microbiology with focus on host-pathogen interactions, and haematology. In this context, integrative interdisciplinary topics (e.g. interaction between immune cells or microbes and tissues, neuroimmunology, etc.) or the use of innovative methodological approaches (e.g. multiplexed spatial imaging, microfluidics, etc.) could be of particular interest.
The INEM is a world-class biomedical research Institute affiliated with Université Paris Cité, CNRS and INSERM. The institute has an international staff of around 300 people from more than 20 countries, partitioned in 21 research teams and administrative support services. The INEM is located in Paris, the French capital and one of the most vibrant cultural scenes in the world. INEM teams collaboratively address multiple facets of fundamental science and translational approaches, promoting a holistic understanding of human pathophysiology that associates expertise in multiple organs and in inter-organ hormonal communications, growth, metabolism, inflammation, immunity and haemato-oncology. To achieve this, the close ties with the clinical services of the Hôpital Necker-Enfants Malades on the joint Necker campus are both a fundamental element and critical asset.
The positions include more than 100m2 lab space with cell culture room and offices, complemented with a competitive start-up package and access to on-site state-of-the-art core facilities (https://www.sfr-necker.fr/). Assistance will be provided for obtaining a tenured position and attracting competitive European funding as well as establishing collaborations within the Necker campus, Université Paris Cité
and the broader Paris area, one of the major science hubs in Europe.
Candidates must have a PhD or MD/PhD. Applicants should submit a single pdf file including (1) a 2-page Curriculum vitae with a list of selected publications, (2) a summary of research accomplishments and future projects (4-page max), (3) a motivation statement for joining INEM (1 page max) and (4) contact information for three referees. Applications should be submitted before August 31st 2023 to directorate-inem@inserm.fr.
Shortlisted applicants will be informed by October 1st and invited on site in Autumn, followed by a second round of interviews to the international scientific advisory board. Final selection is expected to take place in December 2023. Installation will occur starting from January 2025
Postdoctoral Research Fellow position in B cell immunology
Thursday 20 of April, 2023

Position

The group of Matthieu Mahévas and Pascal Chappert at Institut Necker Enfants Malades, Inserm U1151 in Paris, France, is looking for a full-time Postdoctoral Research Fellow to take on an exciting project aimed at understanding the origin and evolution of the anti-type I IFN B cell response in humans. The lab has recently developed original approaches for in depth cellular and molecular characterization of the memory B cells compartment combining single-cell in vitro culture, single-cell transcriptomics and repertoire analysis (Sokal Cell 2021, Sokal Immunity 2021, Sokal Immunity 2022, Chappert Immunity 2022) and have applied them to the study of anti-type-I IFN B cell responses. As a partner of the COVIFERON RHU and of the UNDINE H202 consortium, this project builds on different cohorts of individuals with genetic or acquired anti-type-I IFN auto-immunity to document the repertoire, maturation and long-term stability following an infectious event of the underlying auto-reactive B cell response. The successful applicant will also have the opportunity to collaborate on other ongoing projects in the lab aiming at investigating the underlying mechanisms, cellular populations involved and fundamental steps leading to tolerance breakdown in B cells in a pathological context in Human or, at the opposite side of the spectrum, the establishment of long-lasting immune memory in infectious or vaccinal settings.

Qualifications

The lab is looking for a highly motivated, self-driven, independent and creative candidates with clear interest in cellular and molecular immunology and a willingness to learn. Strong organizational skills and experience with cell culture assays in immunology and multiparametric flow cytometry will be evaluated. Additionally experience with any of these following techniques is a big plus, but not required: mAbs engineering, single-cell RNAseq and TCR/BCR repertoire analysis. The successful candidate will be highly collaborative and expected to thrive as a project leader in an environment with graduate students, engineer etc. Excellent oral and written communication skills (in English) for presenting/discussing research, as well as preparing manuscripts for publication are also required. For additional questions after application, please email bellow.

Description

The position will be opened as of September 1st 2023, with some flexibility. The initial contract would be of 12 to 18 months, with possible extensions until the project is fully completed. Interested applicants are invited to submit a cover letter that includes a brief description of their research background and future interests, their CV, and contact information for three references to Pr. Mahévas, MD PhD or Pascal Chappert, Email: matthieu.mahevas@inserm.fr; pascal.chappert@inserm.fr.

Address

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Support(s)
HRH Princess Caroline of Hanover, who through the Princess Grace Foundation, already supports medical research and anything that helps to relieve the sick children in France and around the world, has agreed to commit to our side so that our Center of Molecular medicine continues to meet the current challenges and fight diseases, and in particular the ones affecting children.

INEM - Organigramme