Grants Project Officer at Institut Necker Enfants Malades, Université Paris Cité – INSERM - CNRS
 
The Institut Necker Enfants Malades (INEM https://www.institut-necker-enfantsmalades.fr/) is seeking a Grants Project Officer to join us on a Fixed Term contract starting in September 2023.
 
The INEM is a world-class biomedical research Institute affiliated with Université Paris Cité, CNRS and INSERM. The institute has an international staff of around 300 people from more than 20 countries, partitioned in 21 research teams and administrative support services. The INEM is located in Paris, the French capital and one of the most vibrant cultural scenes in the world. INEM teams collaboratively address multiple facets of fundamental science and translational approaches, promoting a holistic understanding of human pathophysiology that associates expertise in multiple organs and in inter-organ hormonal communications, growth, metabolism, inflammation, immunity and haemato-oncology. To achieve this, the close ties with the clinical services of the Hôpital Necker-Enfants Malades on the joint Necker campus are both a fundamental element and critical asset.
 
We need the candidate to play a key role in dealing directly with both the principal investigators and the administrative staff from the institution and be expected to identify research funding opportunities then to provide scientific advice, guidance, and recommendations to ensure successful applications and partnerships.
 
Who we are looking for:
 

• Experience of grants management and processes.
• A good working knowledge of project management.
• Team player.
• Highly organized with the ability to work under pressure to set deadlines.

Applicants should submit a single pdf file including (1) a 2-page Curriculum vitae, (2) a motivation letter (1 page max) and contact information for two referees. Applications should be submitted before July 21st 2023 to sabine.barbut@inserm.fr

Post-Doctoral Fellowship in Oncogenic Deregulation of Lymphoid Lineage Specification The Normal and Pathological Lymphoid Differentiation Laboratory from the Institut Necker Enfants Malades (INSERM UMR 1151 research center) is seeking for a PhD trained in hematopoietic stem cell biology
and/or translational leukemia research. Our laboratory investigates the interface between normal and leukemic lymphoid development. We combine a dual expertise in oncogenesis and developmental immunology to dissect the transcriptional and epigenetic events underlying oncogenic arrest during the specification of hematopoietic stem cells (HSC) toward the lymphoid lineage. Our research combines in vivo (HSC xenografts; PDX) and in vitro cellular (multi-lineage diff. assays) and molecular (single cell RNA sequencing, methylome profiling, genome-wide HiC, CUT&Tag) approaches through which understanding the malignant deregulation of early hemato-lymphopoiesis can lead both to targeted and personalized therapeutics. The specific aims of
the current research projects are: (i) to decipher the hierarchy of transcription factors and epigenetic regulators controlling the specification of human HSCs toward the lymphoid lineage; (ii) to characterize the 3D genome alterations caused by oncogenes involved in the pathogenesis of immature T-cell acute
lymphoblastic leukemia. Highly motivated candidates with a Ph.D. or M.D./Ph.D. in developmental immunology and/or hematology are welcome to apply. Applicants should possess strong laboratory, analytical, interpersonal and communication skills. Candidates with previous experience in stem cell biology, multi-omics and statistics are highly desirable.
The “Institut Necker Enfants Malades” (INEM) located in the Necker Hospital (Paris) provides an exceptional scientific and academic environment. Administered jointly by INSERM, CNRS and the Université de Paris, INEM benefits from close contacts with clinicians and state-of-the-art technological platforms in one of France’s foremost research centered universities.
The successful candidate will be offered a 24-to-36-month contract with salary depending on experience.
This position is available immediately, though start date is flexible.
Interested candidates should email a brief cover letter indicating their research interests, experience and career goals, CV, and contact information for 2 references to Pr Bruno Canque (bruno.canque@ephe.psl.eu).
Bruno CANQUE, M.D., Ph.D. and Vahid ASNAFI, M.D., Ph.D.
References :
. Alhaj Hussen, K., et al. (2017). Molecular and Functional Characterization of Lymphoid Progenitor Subsets Reveals a Bipartite Architecture of Human Lymphopoiesis. Immunity 47, 680-696 e688. 10.1016/j.immuni.2017.09.009.
. Cieslak, A., et al. (2020). Blueprint of human thymopoiesis reveals molecular mechanisms of stage-specific TCR enhancer activation. J Exp Med 217. 10.1084/jem.20192360.
. Andrieu, G.P, et al. (2021). PRC2 loss of function confers a targetable vulnerability to BET proteins in T-ALL.  Blood 138, 1855-1869. 10.1182/blood.2020010081.
. Touzart, A., et al. (2021). Epigenetic analysis of patients with T-ALL identifies poor outcomes and a hypomethylating agent-responsive subgroup. Science translational medicine 13. 10.1126/scitranslmed.abc4834
. Keita, S., et al. (2023). Distinct subsets of multi-lymphoid progenitors support ontogeny-related changes in human lymphopoiesis. Cell Rep 42, 112618. 10.1016/j.celrep.2023.112618

The Institut Necker Enfants Malades (INEM, https://www.institut-necker-enfants-malades.fr/) invites applications for two group leader positions. Excellent future prospects and an upwards-scientific track record will be the principal selection criteria. We promote equal opportunities, strongly encouraging applications from female candidates and welcome applications from early career scientists as well as established PIs who wish to join INEM.
Candidates should have an innovative research program complementing the existing strengths in one of the main areas in relation to INEM departments:
1) control of tissue growth, metabolism, organelle homeostasis and interorgan communication at the molecular, cell biology or patho-physiology level. In this context, bringing an expertise in primary cell organoids or organ-on-chip technology might be considered an asset;
2) fundamental and translational studies in immunology, microbiology with focus on host-pathogen interactions, and haematology. In this context, integrative interdisciplinary topics (e.g. interaction between immune cells or microbes and tissues, neuroimmunology, etc.) or the use of innovative methodological approaches (e.g. multiplexed spatial imaging, microfluidics, etc.) could be of particular interest.
The INEM is a world-class biomedical research Institute affiliated with Université Paris Cité, CNRS and INSERM. The institute has an international staff of around 300 people from more than 20 countries, partitioned in 21 research teams and administrative support services. The INEM is located in Paris, the French capital and one of the most vibrant cultural scenes in the world. INEM teams collaboratively address multiple facets of fundamental science and translational approaches, promoting a holistic understanding of human pathophysiology that associates expertise in multiple organs and in inter-organ hormonal communications, growth, metabolism, inflammation, immunity and haemato-oncology. To achieve this, the close ties with the clinical services of the Hôpital Necker-Enfants Malades on the joint Necker campus are both a fundamental element and critical asset.
The positions include more than 100m2 lab space with cell culture room and offices, complemented with a competitive start-up package and access to on-site state-of-the-art core facilities (https://www.sfr-necker.fr/). Assistance will be provided for obtaining a tenured position and attracting competitive European funding as well as establishing collaborations within the Necker campus, Université Paris Cité
and the broader Paris area, one of the major science hubs in Europe.
Candidates must have a PhD or MD/PhD. Applicants should submit a single pdf file including (1) a 2-page Curriculum vitae with a list of selected publications, (2) a summary of research accomplishments and future projects (4-page max), (3) a motivation statement for joining INEM (1 page max) and (4) contact information for three referees. Applications should be submitted before August 31st 2023 to directorate-inem@inserm.fr.
Shortlisted applicants will be informed by October 1st and invited on site in Autumn, followed by a second round of interviews to the international scientific advisory board. Final selection is expected to take place in December 2023. Installation will occur starting from January 2025