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Monday 30 of May, 2016
Regulation of cell size: a novel aspect of primary cilium-dependent autophagy
 
Recently the team 1 showed in collaboration with team 6 and Thierry Capiod (team 4) that autophagy controls epithelial cell size/volume in the kidney proximal tubule. The fluid flow stimulates the induction of autophagy, a degradative mechanism for cytoplasmic material ending up into the lysosomal compartment, via the primary cilium-dependent inhibition of the kinase mTOR.
 

Figure: Increase in the autophagic flux in kidney epithelial cell expressing RFP-GFP-LC3 is detected by the accumulation of red dots (autolysosomes). Yellow dots represent nascent non acidified autophagic vacuoles (autophagosome).

Primary-cilium-dependent autophagy controls epithelial cell volume in response to fluid flow.
Orhon I*, Dupont N*, Zaidan M, Boitez V, Burtin M, Schmitt A, Capiod T, Viau A, Beau I, Kuehn E W , Friedlander G, Terzi F, Codogno P. 2016 Nat Cell Biol. 18:657-67.
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HRH Princess Caroline of Hanover, who through the Princess Grace Foundation, already supports medical research and anything that helps to relieve the sick children in France and around the world, has agreed to commit to our side so that our Center of Molecular medicine continues to meet the current challenges and fight diseases, and in particular the ones affecting children.

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