Hosted by
Institut Necker Enfants-Malades (INEM – INSERM U1151 / CNRS UMR 8253)
Laboratoire Interuniversitaire des Systèmes Atmosphériques (LISA – CNRS UMR 7583)

A 3-year PhD position is available for a highly motivated and hard-working candidate to investigate the role of atmospheric particulate matter in the progression of chronic kidney disease (CKD). The position is funded by a Crossing Cutting Edge Grant from Université Paris Cité and offers a stimulating interdisciplinary environment at the interface of biomedical and environmental sciences.

Host Institutes

Institut Necker-Enfants Malades (INEM) is a biomedical research center created in 2014 and located on the Necker campus in central Paris. It is supported by INSERM, CNRS, and Université Paris Cité. The Necker campus brings together the Necker-Enfants Malades Hospital and two major research institutes: INEM and the Institut Imagine. INEM hosts over 250 researchers and staff working on metabolism, immunology, infectious diseases, and other biomedical topics. INEM benefits from access to multiple core facilities including an animal house (with zebrafish), histology, flow cytometry, imaging, genomics, bioinformatics, proteomics, viral production, and metabolomics platforms.

Laboratoire Interuniversitaire des Systèmes Atmosphériques (LISA) is a joint research unit of CNRS, Université Paris Cité, and Université Paris-Est Créteil. It is part of the EFLUVE Observatory and of the Institut Pierre Simon Laplace (IPSL), a federation of six environmental and climate science labs in the Paris region. LISA's research focuses on understanding the dynamics of terrestrial and planetary atmospheres and the environmental impacts of human-induced changes in atmospheric composition, using in situ observations, experimental simulations, and numerical modeling.

Project Description
The PhD project will involve experimental work on mouse models of CKD and kidney epithelial cells using in vitro microfluidic approaches. Both in vivo and in vitro systems will be exposed to realistic polluted atmospheres containing particulate matter, using the PolluRisk platform developed at LISA. 

Candidate Profile
Applicants should have a background in physiology and cell biology. Experience in kidney physiology/ pathophysiology, toxicology, or animal models is strongly encouraged.

Salary
The position is funded by Université Paris Cité and salary is according to university guidelines.

Application Procedure
Please send: a concise cover letter outlining your research interests and previous experience, your CV, and two reference letters to Nicolas Dupont and Patrice Coll at the following emails: @email ; @email. 

Deadline 
September 1st, 2025

Contact Information

• Dr. Nicolas Dupont
  INEM – INSERM U1151
  156 Rue de Vaugirard, 75015 Paris, France
   
• Pr. Patrice Coll
  LISA – UMR 7583
  Campus Centre UPEC
  61 avenue du Général de Gaulle, 94010 Créteil Cedex, France

Starting Date: between November and December 2025